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IL9R interleukin 9 receptor [ Homo sapiens (human) ]

Gene ID: 3581, updated on 24-Nov-2020

Summary

Official Symbol
IL9Rprovided by HGNC
Official Full Name
interleukin 9 receptorprovided by HGNC
Primary source
HGNC:HGNC:6030
See related
Ensembl:ENSG00000124334 MIM:300007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD129; IL-9R
Summary
The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Biased expression in urinary bladder (RPKM 2.4), lymph node (RPKM 1.3) and 11 other tissues See more
Orthologs

Genomic context

See IL9R in Genome Data Viewer
Location:
Xq28 and Yq12
Exon count:
14
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (155997631..156013017)
109.20201120 current GRCh38.p13 (GCF_000001405.39) Y NC_000024.10 (57184151..57199537)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (155227246..155240482)
105 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (59330252..59343488)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene elongin C pseudogene 24 Neighboring gene transient receptor potential cation channel subfamily C member 6, pseudogene Neighboring gene WASH and IL9R antisense RNA 1 Neighboring gene WASP family homolog 6, pseudogene Neighboring gene DEAD/H-box helicase 11 like 16 (pseudogene)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene elongin C pseudogene 24 Neighboring gene transient receptor potential cation channel subfamily C member 6, pseudogene Neighboring gene WASH and IL9R antisense RNA 1 Neighboring gene WASP family homolog 6, pseudogene Neighboring gene DEAD/H-box helicase 11 like 16 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV Vif interacts with IL9R PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-9 receptor activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
interleukin-9-mediated signaling pathway TAS
Traceable Author Statement
more info
 
regulation of cell population proliferation TAS
Traceable Author Statement
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
extracellular space TAS
Traceable Author Statement
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-9 receptor
Names
IL-9 receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013238.1 RefSeqGene

    Range
    5116..18237
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002186.3NP_002177.2  interleukin-9 receptor isoform 1 precursor

    See identical proteins and their annotated locations for NP_002177.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    BC025298, M84747
    Consensus CDS
    CCDS14771.4
    UniProtKB/Swiss-Prot
    Q01113
    Related
    ENSP00000244174.5, ENST00000244174.10
  2. NM_176786.2NP_789743.2  interleukin-9 receptor isoform 2

    See identical proteins and their annotated locations for NP_789743.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. it initiates translation at an alternate start codon. The resulting isoform (2) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AJ271736, BC025298
    Consensus CDS
    CCDS59180.1
    UniProtKB/Swiss-Prot
    Q01113
    Related
    ENSP00000358431.2, ENST00000369423.7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    155997631..156013017
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029504.1XP_016884993.1  interleukin-9 receptor isoform X12

  2. XM_017029500.1XP_016884989.1  interleukin-9 receptor isoform X6

  3. XM_017029496.1XP_016884985.1  interleukin-9 receptor isoform X4

  4. XM_011531155.2XP_011529457.1  interleukin-9 receptor isoform X7

    See identical proteins and their annotated locations for XP_011529457.1

  5. XM_017029505.1XP_016884994.1  interleukin-9 receptor isoform X13

  6. XM_011531156.2XP_011529458.1  interleukin-9 receptor isoform X8

    See identical proteins and their annotated locations for XP_011529458.1

  7. XM_011531157.2XP_011529459.1  interleukin-9 receptor isoform X14

    See identical proteins and their annotated locations for XP_011529459.1

  8. XM_017029501.1XP_016884990.1  interleukin-9 receptor isoform X9

  9. XM_017029495.1XP_016884984.1  interleukin-9 receptor isoform X2

  10. XM_011531151.2XP_011529453.1  interleukin-9 receptor isoform X1

    See identical proteins and their annotated locations for XP_011529453.1

  11. XM_011531152.2XP_011529454.1  interleukin-9 receptor isoform X3

    See identical proteins and their annotated locations for XP_011529454.1

  12. XM_017029502.1XP_016884991.1  interleukin-9 receptor isoform X10

  13. XM_017029497.1XP_016884986.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  14. XM_011531154.2XP_011529456.1  interleukin-9 receptor isoform X5

    See identical proteins and their annotated locations for XP_011529456.1

    UniProtKB/Swiss-Prot
    Q01113
  15. XM_017029503.1XP_016884992.1  interleukin-9 receptor isoform X11

  16. XM_017029498.1XP_016884987.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  17. XM_017029499.1XP_016884988.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  18. XM_017029506.1XP_016884995.1  interleukin-9 receptor isoform X15

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p13 Primary Assembly

    Range
    57184151..57199537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017030053.1XP_016885542.1  interleukin-9 receptor isoform X12

  2. XM_017030049.1XP_016885538.1  interleukin-9 receptor isoform X6

  3. XM_017030045.1XP_016885534.1  interleukin-9 receptor isoform X4

  4. XM_011545650.2XP_011543952.1  interleukin-9 receptor isoform X7

    See identical proteins and their annotated locations for XP_011543952.1

  5. XM_017030054.1XP_016885543.1  interleukin-9 receptor isoform X13

  6. XM_011545651.2XP_011543953.1  interleukin-9 receptor isoform X8

    See identical proteins and their annotated locations for XP_011543953.1

  7. XM_011545652.2XP_011543954.1  interleukin-9 receptor isoform X14

    See identical proteins and their annotated locations for XP_011543954.1

  8. XM_017030050.1XP_016885539.1  interleukin-9 receptor isoform X9

  9. XM_017030044.1XP_016885533.1  interleukin-9 receptor isoform X2

  10. XM_011545645.2XP_011543947.1  interleukin-9 receptor isoform X1

    See identical proteins and their annotated locations for XP_011543947.1

  11. XM_011545646.2XP_011543948.1  interleukin-9 receptor isoform X3

    See identical proteins and their annotated locations for XP_011543948.1

  12. XM_017030051.1XP_016885540.1  interleukin-9 receptor isoform X10

  13. XM_017030046.1XP_016885535.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  14. XM_011545649.2XP_011543951.1  interleukin-9 receptor isoform X5

    See identical proteins and their annotated locations for XP_011543951.1

    UniProtKB/Swiss-Prot
    Q01113
  15. XM_017030052.1XP_016885541.1  interleukin-9 receptor isoform X11

  16. XM_017030047.1XP_016885536.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  17. XM_017030048.1XP_016885537.1  interleukin-9 receptor isoform X5

    UniProtKB/Swiss-Prot
    Q01113
  18. XM_017030055.1XP_016885544.1  interleukin-9 receptor isoform X15

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