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Lpin Lipin [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35790, updated on 8-Oct-2018

Summary

Official Symbol
Lpinprovided by FlyBase
Official Full Name
Lipinprovided by FlyBase
Primary source
FLYBASE:FBgn0263593
Locus tag
Dmel_CG8709
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.133; CG8709; dLipin; DLpin; Dmel\CG8709; DmLpin; EP2431; LIPIN

Genomic context

See Lpin in Genome Data Viewer
Location:
44B4-44B5; 2-58 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (8136986..8156654, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (4024491..4044159, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Suppressor of Cytokine Signaling at 44A Neighboring gene uncharacterized protein Neighboring gene PSEA-binding protein 49kD Neighboring gene Pabp2 Neighboring gene Odorant-binding protein 44a Neighboring gene kermit Neighboring gene transfer RNA:Isoleucine-AAT 1-2 Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
phosphatidate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription coactivator activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
cellular response to insulin stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to insulin stimulus IGI
Inferred from Genetic Interaction
more info
PubMed 
cellular response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
fatty acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of BMP signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of phosphatidylinositol 3-kinase signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of cellular ketone metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of fatty acid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to starvation IMP
Inferred from Mutant Phenotype
more info
PubMed 
triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
triglyceride biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
female germline ring canal inner rim IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
lipin
Names
CG8709-PA
CG8709-PB
CG8709-PC
CG8709-PD
CG8709-PE
CG8709-PG
CG8709-PH
CG8709-PJ
CG8709-PK
CG8709-PL
CG8709-PM
DmLipin
EP2431
Lpin-PA
Lpin-PB
Lpin-PC
Lpin-PD
Lpin-PE
Lpin-PG
Lpin-PH
Lpin-PJ
Lpin-PK
Lpin-PL
Lpin-PM
dLipin
NP_001097228.1
NP_001188874.1
NP_001188875.1
NP_001188876.1
NP_001188878.1
NP_001188879.1
NP_001188881.1
NP_001188882.1
NP_001188883.1
NP_001188884.1
NP_610359.2

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    8136986..8156654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001201953.3NP_001188882.1  lipin, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188882.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY69
    Related
    FBpp0292616, FBtr0303583
    Conserved Domains (4) summary
    pfam15017
    Location:9751028
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:760984
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:562671
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  2. NM_001201945.2NP_001188874.1  lipin, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188874.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD00
    Related
    FBpp0292606, FBtr0303573
    Conserved Domains (4) summary
    pfam15017
    Location:9741027
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:759983
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:561670
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  3. NM_001201954.2NP_001188883.1  lipin, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188883.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD31
    Related
    FBpp0292617, FBtr0303584
    Conserved Domains (4) summary
    pfam15017
    Location:932985
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:717941
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:562628
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  4. NM_001103758.3NP_001097228.1  lipin, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001097228.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A8DY69
    Related
    FBpp0111968, FBtr0113055
    Conserved Domains (4) summary
    pfam15017
    Location:9751028
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:760984
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:562671
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  5. NM_001201952.1NP_001188881.1  lipin, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188881.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E5DK16
    Related
    FBpp0292613, FBtr0303580
    Conserved Domains (4) summary
    pfam15017
    Location:902955
    AF1Q; Drug resistance and apoptosis regulator
    pfam04571
    Location:130
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:687911
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:489598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  6. NM_001201955.2NP_001188884.1  lipin, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXP0
    Related
    FBpp0292618, FBtr0303585
    Conserved Domains (3) summary
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:760985
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:562671
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  7. NM_001201950.2NP_001188879.1  lipin, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188879.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I0E2I4
    Related
    FBpp0292611, FBtr0303578
    Conserved Domains (3) summary
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:714939
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:516625
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  8. NM_136515.3NP_610359.2  lipin, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610359.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8SXP0
    Related
    FBpp0087891, FBtr0088815
    Conserved Domains (3) summary
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:760985
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:562671
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  9. NM_001201947.2NP_001188876.1  lipin, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188876.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JD27
    Related
    FBpp0292608, FBtr0303575
    Conserved Domains (3) summary
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:716941
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:561627
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  10. NM_001201946.2NP_001188875.1  lipin, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCQ5
    Related
    FBpp0292607, FBtr0303574
    Conserved Domains (3) summary
    pfam04571
    Location:1103
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:759984
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:561670
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
  11. NM_001201949.1NP_001188878.1  lipin, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188878.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4JCS1
    Related
    FBpp0292610, FBtr0303577
    Conserved Domains (3) summary
    pfam04571
    Location:130
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:687912
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:489598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
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