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CXCR1 C-X-C motif chemokine receptor 1 [ Homo sapiens (human) ]

Gene ID: 3577, updated on 28-Nov-2021

Summary

Official Symbol
CXCR1provided by HGNC
Official Full Name
C-X-C motif chemokine receptor 1provided by HGNC
Primary source
HGNC:HGNC:6026
See related
Ensembl:ENSG00000163464 MIM:146929
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C-C; CD128; CD181; CKR-1; IL8R1; IL8RA; CMKAR1; IL8RBA; CDw128a; C-C-CKR-1
Summary
The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. [provided by RefSeq, Jul 2008]
Expression
Biased expression in appendix (RPKM 17.0), spleen (RPKM 9.7) and 6 other tissues See more
Orthologs
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Genomic context

See CXCR1 in Genome Data Viewer
Location:
2q35
Exon count:
2
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (218162841..218166962, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (219027564..219031685, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene RUN and FYVE domain containing 4 Neighboring gene Sharpr-MPRA regulatory region 3825 Neighboring gene C-X-C motif chemokine receptor 2 Neighboring gene high mobility group box 1 pseudogene 9 Neighboring gene uncharacterized LOC101928487

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.
GeneReviews: Not available
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
GeneReviews: Not available
Human immunodeficiency virus type 1, susceptibility to
MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
Compare labs
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Progressive HIV-1 infection is linked to upregulated CXCL8 (IL8), CXCR1, and PTPN11 (SHP2) expression in PBMC samples from HIV-1 infected children PubMed

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 Nef induces variable levels of CXCR1 downregulation in different cell types PubMed
capsid gag CXCL8-induced upregulation of HIV-1 p24 levels and 2-LTR cycles is inhibited by CXCR1 or CXCR2 neutralization in HIV-1-infected monocytes-derived macrophages PubMed
matrix gag CXCR1-expressing Jurkat cells can migrate in response to HIV-1 MA, but cannot activate ERK1/2 signaling pathway and intracellular calcium mobilization PubMed
gag Surface plasmon resonance (SPR) binding assay demonstrates that HIV-1 MA and SIV MA bind CXCR1 with similar affinities PubMed
gag The N-terminal basic motif (residues 25-34) of HIV-1 MA is required for its binding to CXCR1, while heparin and heparin sulfate also bind to the basic motif PubMed
gag HIV-1 p17 induces capillary-like structures in human endothelial cells by binding to CXCR1 and CXCR2, which requires activation of the Akt-dependent ERK signaling pathway PubMed
gag HIV-1 p17-induced monocyte migratory activity is regulated by the p17/CRCX1 interaction PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables C-C chemokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables C-C chemokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables chemokine receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables interleukin-8 binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables interleukin-8 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in calcium-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell surface receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemokine-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in dendritic cell chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in interleukin-8-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in neutrophil chemotaxis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in receptor internalization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C-X-C chemokine receptor type 1
Names
CXC-R1
CXCR-1
IL-8 receptor type 1
IL-8R A
chemokine (C-X-C motif) receptor 1
high affinity interleukin-8 receptor A
interleukin 8 receptor, alpha
interleukin-8 receptor type 1
interleukin-8 receptor type A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011814.1 RefSeqGene

    Range
    5032..9153
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000634.3NP_000625.1  C-X-C chemokine receptor type 1

    See identical proteins and their annotated locations for NP_000625.1

    Status: REVIEWED

    Source sequence(s)
    AC097483
    Consensus CDS
    CCDS2409.1
    UniProtKB/Swiss-Prot
    P25024
    Related
    ENSP00000295683.2, ENST00000295683.3
    Conserved Domains (1) summary
    pfam00001
    Location:56305
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    218162841..218166962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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