Odc1 Ornithine decarboxylase 1 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Odc1provided by FlyBase
Official Full Name: Ornithine decarboxylase 1provided by FlyBase
Primary source: FLYBASE:FBgn0013307
Locus tag: Dmel_CG8721
See related: AllianceGenome:FB:FBgn0013307
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8721; Dmel\CG8721; dodc1; Odc-1
Summary: Predicted to enable ornithine decarboxylase activity. Predicted to be involved in putrescine biosynthetic process from arginine, via ornithine. Predicted to be active in cytoplasm. Is expressed in embryonic/larval fat body. Human ortholog(s) of this gene implicated in esophagus squamous cell carcinoma; hepatocellular carcinoma; and liver cirrhosis. Orthologous to several human genes including AZIN2 (antizyme inhibitor 2) and ODC1 (ornithine decarboxylase 1). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (8004824..8006672)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (3892329..3894177)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila.
Title: The regulation of triglyceride storage by ornithine decarboxylase (Odc1) in Drosophila.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables carboxy-lyase activity	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables ornithine decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in putrescine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in putrescine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IC Inferred by Curator more info

Names: CG8721-PA; Odc1-PA; ornithine decarboxylase; ornithine decarboxylase-1

NP_477052.2

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The following sections contain reference sequences that belong to a specific genome build. Explain