U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

drosha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35747, updated on 5-Jan-2023

Summary

Official Symbol
droshaprovided by FlyBase
Primary source
FLYBASE:FBgn0026722
Locus tag
Dmel_CG8730
See related
AllianceGenome:FB:FBgn0026722
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG8730; Dmel\CG8730; Drosha; DROSHA
Summary
Predicted to enable double-stranded RNA binding activity and ribonuclease III activity. Involved in several processes, including germarium-derived egg chamber formation; mushroom body development; and production of miRNAs involved in gene silencing by miRNA. Part of microprocessor complex. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Apr 2022]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See drosha in Genome Data Viewer
Location:
43F2-43F3; 2-57 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.46 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7932429..7936840)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3819934..3824345)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X Neighboring gene ribonuclease H1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in germarium-derived female germ-line cyst formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germarium-derived oocyte fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mushroom body development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in pre-miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary miRNA processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 
involved_in salivary gland histolysis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of microprocessor complex IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
drosha
Names
CG8730-PA
drosha-PA
NP_477436.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7932429..7936840
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058088.4NP_477436.1  drosha [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477436.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KNF1
    Related
    FBpp0087926, FBtr0088850
    Conserved Domains (5) summary
    smart00535
    Location:9901117
    RIBOc; Ribonuclease III family
    COG0571
    Location:738974
    Rnc; dsRNA-specific ribonuclease [Transcription]
    PRK00102
    Location:9731196
    rnc; ribonuclease III; Reviewed
    cd00048
    Location:11251196
    DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
    pfam12413
    Location:64136
    DLL_N; Homeobox protein distal-less-like N terminal