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Cul1 Cullin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35742, updated on 26-Aug-2021

Summary

Official Symbol
Cul1provided by FlyBase
Official Full Name
Cullin 1provided by FlyBase
Primary source
FLYBASE:FBgn0015509
Locus tag
Dmel_CG1877
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1877; cul-1; Cul-1; cul1; CUL1; Cullin-1; Cullin1; dCul-1; dCul1; dCUL1; dmCUL1; Dmel\CG1877; l(2)02074; l(2)k01207; lin 19; Lin-19; lin-19/cul-1; lin19; Lin19; lin19-like; Q9V312
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Genomic context

See Cul1 in Genome Data Viewer
Location:
43F1-43F2; 2-57 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7916856..7921579)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3804361..3809084)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Autophagy-related 10 Neighboring gene Diacyl glycerol kinase Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Odorant receptor 43b Neighboring gene Lysine (K)-specific demethylase 4A Neighboring gene Major Facilitator Superfamily Transporter 12 Neighboring gene Phosphatidylinositol glycan anchor biosynthesis class X

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

  • Homologs of the Cul1 gene: The Cul1 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.pombe, M.oryzae, N.crassa, and frog.
  • Orthologs

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular adaptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of peptidoglycan recognition protein signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phosphatidylinositol 3-kinase signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein kinase B signaling IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synaptonemal complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IC
Inferred by Curator
more info
PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of SCF ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of SCF ubiquitin ligase complex IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of cullin-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cullin 1
Names
CG1877-PA
CG1877-PB
CG1877-PC
CG1877-PD
Cul1-PA
Cul1-PB
Cul1-PC
Cul1-PD
cullin
cullin-1
cullin1
dCullin
dCullin1
lin-19-like
lin19-like

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    7916856..7921579
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165571.2NP_724623.1  cullin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724623.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24311
    Related
    FBpp0087921, FBtr0088845
    Conserved Domains (3) summary
    smart00182
    Location:454593
    CULLIN; Cullin
    smart00884
    Location:701765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21669
    Cullin; Cullin family
  2. NM_165570.3NP_724622.1  cullin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724622.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24311
    Related
    FBpp0087922, FBtr0088846
    Conserved Domains (3) summary
    smart00182
    Location:454593
    CULLIN; Cullin
    smart00884
    Location:701765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21669
    Cullin; Cullin family
  3. NM_165569.2NP_724621.1  cullin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724621.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24311
    Related
    FBpp0087923, FBtr0088847
    Conserved Domains (3) summary
    smart00182
    Location:454593
    CULLIN; Cullin
    smart00884
    Location:701765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21669
    Cullin; Cullin family
  4. NM_078931.4NP_523655.1  cullin 1, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523655.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q24311
    Related
    FBpp0087924, FBtr0088848
    Conserved Domains (3) summary
    smart00182
    Location:454593
    CULLIN; Cullin
    smart00884
    Location:701765
    Cullin_Nedd8; Cullin protein neddylation domain
    pfam00888
    Location:21669
    Cullin; Cullin family
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