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IL7 interleukin 7 [ Homo sapiens (human) ]

Gene ID: 3574, updated on 7-Oct-2018

Summary

Official Symbol
IL7provided by HGNC
Official Full Name
interleukin 7provided by HGNC
Primary source
HGNC:HGNC:6023
See related
Ensembl:ENSG00000104432 MIM:146660; Vega:OTTHUMG00000164620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IL-7
Summary
The protein encoded by this gene is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their presence in normal tissues has not been confirmed.[provided by RefSeq, Dec 2010]
Expression
Broad expression in lymph node (RPKM 2.7), skin (RPKM 2.5) and 24 other tissues See more
Orthologs

Genomic context

See IL7 in Genome Data Viewer
Location:
8q21.13
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (78675870..78806830, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (79645007..79717758, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375911 Neighboring gene RNA, U6 small nuclear 1220, pseudogene Neighboring gene PKIA antisense RNA 1 Neighboring gene cAMP-dependent protein kinase inhibitor alpha Neighboring gene chromosome 4 open reading frame 46 pseudogene Neighboring gene zinc finger C2HC-type containing 1A Neighboring gene uncharacterized LOC105375914 Neighboring gene THAP domain containing 12 pseudogene 7 Neighboring gene uncharacterized LOC105375912 Neighboring gene uncharacterized LOC105375913 Neighboring gene uncharacterized LOC107986892

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Clinical samples of cerebrospinal fluid from patients infected with HIV-1 subtypes B and C exhibited upregulated levels of IL7, IL10, CXCL10 (IP10), CCL2 (MCP1), and CCL3 (MIP1A) PubMed
HIV-1 replication in resting peripheral blood CD4 T cells is rescued by IL7; IL7 rescues resting peripheral blood CD4 T cells from HIV-1-induced T cell death PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120-induced neuronal apoptosis is augmented by IL-7 PubMed
Envelope surface glycoprotein gp160, precursor env IL-7-treated resting CD4+ T cells produce more Env protein than untreated cells PubMed
env IL-7 and IL-12 significantly augment proliferative responses to HIV-1 gp160 PubMed
Pr55(Gag) gag IL-7-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells PubMed
Tat tat HIV-1 Tat inhibits IL7-induced upregulation of BCL-2 in CD4 T-cells PubMed
tat HIV-1 Tat inhibits the effects of IL-7 on activation of CD8 T-cells signaling via IL-7R PubMed
tat Upregulation of intracellular perforin accumulation by IL-7 in CD4 or CD8 T-cells is inhibited by HIV-1 Tat PubMed
tat HIV-1 Tat-mediated degradation of IL-7R alpha-chain (CD127) from the surface of resting CD8 T cells leads to reduced IL-7 signaling and to impaired CD8 T cell proliferation and function PubMed
tat HIV-1 Tat and IL-7 act synergistically to downregulate CD127 on CD8+ T cells. Downregulation of CD127 by IL-7 requires JAK activation pathway PubMed
capsid gag Unactivated memory CD4+ T cells infected by HIV-1 in the presence of IL-2 and IL-15 alone or IL-6/IL-7/TNF-alpha combination, upregulate granzyme B and HIV-1 CA production PubMed
integrase gag-pol IL-7 and CD95 synergistically promote survival and proliferation of HIV-1-latently infected CD4+ T-cells measured by increased levels of integrated HIV-1 DNA, suggesting that HIV-1 IN interacts with IL-7 and CD95 in latently infected CD4+ T-cells PubMed
gag-pol Treatment of resting CD4+ T cells with cytokines IL-2, IL-4, IL-7, or IL15 enhances HIV-1 IN mutant D116N to generate de novo virus production PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokines and Inflammatory Response, organism-specific biosystem (from WikiPathways)
    Cytokines and Inflammatory Response, organism-specific biosystemInflammation is a protective response to infection by the immune system that requires communication between different classes of immune cells to coordinate their actions. Acute inflammation is an imp...
  • Development and heterogeneity of the ILC family, organism-specific biosystem (from WikiPathways)
    Development and heterogeneity of the ILC family, organism-specific biosystemDevelopment and heterogeneity of the ILC family. ILCs develop from distinct progenitors in the fetal liver or bone marrow and then develop into mature ILCs in the periphery. Different transcription f...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • IL-7 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-7 Signaling Pathway, organism-specific biosystemInterleukin-7 (IL-7) was discovered in the year 1988 as a factor that enhanced the growth of murine B-cell precursors in bone marrow culture system. It was also known as lymphopoietin 1and pre-B cell...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Interleukin-7 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-7 signaling, organism-specific biosystemInterleukin-7 (IL7) is produced primarily by T zone fibroblastic reticular cells found in lymphoid organs, and also expressed by non-hematopoietic stromal cells present in other tissues including the...
  • Jak-STAT signaling pathway, organism-specific biosystem (from KEGG)
    Jak-STAT signaling pathway, organism-specific biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • Jak-STAT signaling pathway, conserved biosystem (from KEGG)
    Jak-STAT signaling pathway, conserved biosystemThe Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathway is one of a handful of pleiotropic cascades used to transduce a multitude of signals for development and homeost...
  • PI3K-Akt signaling pathway, organism-specific biosystem (from KEGG)
    PI3K-Akt signaling pathway, organism-specific biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • PI3K-Akt signaling pathway, conserved biosystem (from KEGG)
    PI3K-Akt signaling pathway, conserved biosystemThe phosphatidylinositol 3' -kinase(PI3K)-Akt signaling pathway is activated by many types of cellular stimuli or toxic insults and regulates fundamental cellular functions such as transcription, tra...
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
growth factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
interleukin-7 receptor binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
T cell lineage commitment IEA
Inferred from Electronic Annotation
more info
 
animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
bone resorption ISS
Inferred from Sequence or Structural Similarity
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
homeostasis of number of cells within a tissue IEA
Inferred from Electronic Annotation
more info
 
humoral immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of catalytic activity IEA
Inferred from Electronic Annotation
more info
 
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
Inferred from Electronic Annotation
more info
 
positive regulation of B cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of T cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of chemokine production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cytokine-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of organ growth IEA
Inferred from Electronic Annotation
more info
 
regulation of gene expression IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
collagen-containing extracellular matrix HDA PubMed 
extracellular region IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000880.3NP_000871.1  interleukin-7 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000871.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK291538, BC047698, J04156
    Consensus CDS
    CCDS6224.1
    UniProtKB/Swiss-Prot
    P13232
    UniProtKB/TrEMBL
    A8K673
    Related
    ENSP00000263851.4, OTTHUMP00000227044, ENST00000263851.8, OTTHUMT00000379429
    Conserved Domains (1) summary
    smart00127
    Location:27173
    IL7; Interleukin-7 and interleukin-9 family
  2. NM_001199886.1NP_001186815.1  interleukin-7 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001186815.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (2) compared to isoform 1.
    Source sequence(s)
    AB102879, AK291538, BC047698
    Consensus CDS
    CCDS56541.1
    UniProtKB/Swiss-Prot
    P13232
    UniProtKB/TrEMBL
    A8K673
    Related
    ENSP00000427750.1, OTTHUMP00000227046, ENST00000520269.5, OTTHUMT00000379431
    Conserved Domains (1) summary
    cl11602
    Location:27129
    IL7; Interleukin 7/9 family
  3. NM_001199887.1NP_001186816.1  interleukin-7 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001186816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the 3' coding region, compared to variant 1, which results in a shorter isoform (3) compared to isoform 1.
    Source sequence(s)
    AK291538, BC047698, CD013923
    Consensus CDS
    CCDS75756.1
    UniProtKB/Swiss-Prot
    P13232
    UniProtKB/TrEMBL
    A0A0A0MTG5, A8K673
    Related
    ENSP00000438922.2, ENST00000541183.2
    Conserved Domains (1) summary
    cl11602
    Location:27155
    IL7; Interleukin 7/9 family
  4. NM_001199888.1NP_001186817.1  interleukin-7 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001186817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks multiple in-frame exons in the 3' coding region, compared to variant 1, which result in a shorter isoform (4) compared to isoform 1.
    Source sequence(s)
    AB102893, AK291538, BC047698
    Consensus CDS
    CCDS75755.1
    UniProtKB/Swiss-Prot
    P13232
    UniProtKB/TrEMBL
    A8K673, Q5FBX5
    Related
    ENSP00000368408.3, ENST00000379113.6
    Conserved Domains (1) summary
    cl11602
    Location:27111
    IL7; Interleukin 7/9 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    78675870..78806830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011517523.3XP_011515825.1  interleukin-7 isoform X2

    Conserved Domains (1) summary
    cl11602
    Location:27138
    IL7; Interleukin 7/9 family
  2. XM_011517522.3XP_011515824.1  interleukin-7 isoform X1

    Conserved Domains (1) summary
    cl11602
    Location:27138
    IL7; Interleukin 7/9 family
  3. XM_017013397.2XP_016868886.1  interleukin-7 isoform X3

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