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sta-2 Signal transducer and activator of transcription b [ Caenorhabditis elegans ]

Gene ID: 3565291, updated on 5-Aug-2022

Summary

Gene symbol
sta-2
Gene description
Signal transducer and activator of transcription b
Primary source
WormBase:WBGene00010251
Locus tag
CELE_F58E6.1
See related
AllianceGenome:WB:WBGene00010251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in defense response to fungus; positive regulation of antifungal peptide production; and response to wounding. Located in several cellular components, including apical part of cell; endocytic vesicle; and hemidesmosome. Part of hemidesmosome associated protein complex. Is expressed in hypodermis; interfacial epithelial cell; intestine; and vulva. Human ortholog(s) of this gene implicated in growth hormone insensitivity syndrome with immune dysregulation 1; growth hormone insensitivity syndrome with immune dysregulation 2; lipoid nephrosis; prostate carcinoma; and urinary schistosomiasis. Orthologous to human STAT5A (signal transducer and activator of transcription 5A); STAT5B (signal transducer and activator of transcription 5B); and STAT6 (signal transducer and activator of transcription 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See sta-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (9741206..9744331)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene AQuaPorin or aquaglyceroporin related Neighboring gene RING-CH-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to fungus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of antifungal peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in receptor signaling pathway via JAK-STAT IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of hemidesmosome associated protein complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Signal transducer and activator of transcription b
NP_001122963.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    9741206..9744331
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129491.3NP_001122963.1  Signal transducer and activator of transcription b [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122963.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20977, Q9U9L4
    Conserved Domains (2) summary
    cd09919
    Location:433545
    SH2_STAT_family; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) family
    pfam02864
    Location:167359
    STAT_bind; STAT protein, DNA binding domain