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IL2RG interleukin 2 receptor subunit gamma [ Homo sapiens (human) ]

Gene ID: 3561, updated on 2-Aug-2020

Summary

Official Symbol
IL2RGprovided by HGNC
Official Full Name
interleukin 2 receptor subunit gammaprovided by HGNC
Primary source
HGNC:HGNC:6010
See related
Ensembl:ENSG00000147168 MIM:308380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P64; CIDX; IMD4; CD132; SCIDX; IL-2RG; SCIDX1
Summary
The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010]
Expression
Biased expression in lymph node (RPKM 112.7), appendix (RPKM 78.7) and 12 other tissues See more
Orthologs

Genomic context

See IL2RG in Genome Data Viewer
Location:
Xq13.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (71107404..71111577, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (70327254..70331481, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene sorting nexin 12 Neighboring gene forkhead box O4 Neighboring gene chromosome X open reading frame 65 Neighboring gene mediator complex subunit 12 Neighboring gene neuroligin 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The inhibition of IL-2R expression and proliferation induced by the interaction of CD4 with HIV-1 envelope glycoprotein gp120 is correlated with the inhibition of expression and activation of Janus kinase JAK3 PubMed
env HIV-1 gp120 exerts a dose-dependent reduction of IL-2 mRNA expression, IL-2 production, and surface IL-2 receptor expression in CD4+ lymphocytes PubMed
Envelope surface glycoprotein gp160, precursor env HIV-1 gp160 interacts with IL2RG (CD132); predicted interaction to be relevant to viral egress at plasma membrane/extracellular matrix PubMed
Vpu vpu HIV-1 Vpu downregulates the cell surface expression of interleukin 2 receptor, gamma (IL2RG, CD132) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cytokine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interleukin-15 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-2 binding ISS
Inferred from Sequence or Structural Similarity
more info
 
contributes_to interleukin-2 receptor activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to interleukin-4 receptor activity TAS
Traceable Author Statement
more info
PubMed 
contributes_to interleukin-7 receptor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
immune response TAS
Traceable Author Statement
more info
PubMed 
interleukin-15-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
interleukin-15-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-2-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-21-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-4-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 
interleukin-7-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interleukin-9-mediated signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell surface IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endosome TAS
Traceable Author Statement
more info
 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
external side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane HDA PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
cytokine receptor common subunit gamma
Names
CD132 antigen
IL-2 receptor subunit gamma
IL-2R subunit gamma
common cytokine receptor gamma chain
gammaC
interleukin 2 receptor, gamma
nonfunctional common cytokine receptor gamma chain

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_009088.1 RefSeqGene

    Range
    4923..9150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_150

mRNA and Protein(s)

  1. NM_000206.3NP_000197.1  cytokine receptor common subunit gamma precursor

    See identical proteins and their annotated locations for NP_000197.1

    Status: REVIEWED

    Source sequence(s)
    BC014972, DC345219
    Consensus CDS
    CCDS14406.1
    UniProtKB/Swiss-Prot
    P31785
    Related
    ENSP00000363318.2, ENST00000374202.6
    Conserved Domains (2) summary
    cd00063
    Location:154246
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cl21522
    Location:59151
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    71107404..71111577 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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