Rab2 Rab2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Rab2provided by FlyBase
Official Full Name: Rab2provided by FlyBase
Primary source: FLYBASE:FBgn0014009
Locus tag: Dmel_CG3269
See related: AllianceGenome:FB:FBgn0014009
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG3269; Dmel\CG3269; DmRab2; Drab2; DRab2; DRAB2; O18333; rab2
Summary: Enables GTP binding activity and magnesium ion binding activity. Involved in several processes, including T-tubule organization; regulation of glutamate receptor clustering; and vesicle organization. Located in several cellular components, including endoplasmic reticulum exit site; type II terminal bouton; and vacuolar membrane. Is expressed in several structures, including brain; glial cell; imaginal disc; mushroom body; and synaptic neuropil domain. Orthologous to several human genes including RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (6696739..6699469)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (2584244..2586974)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
enables magnesium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Rab protein signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-tubule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in autophagosome-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein secretion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of glutamate receptor clustering	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secretory granule-lysosome fusion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in symbiont entry into host cell	HMP more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in autolysosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in autophagosome membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum exit site	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in postsynapse of neuromuscular junction	IDA Inferred from Direct Assay more info	PubMed
located_in type II terminal bouton	IDA Inferred from Direct Assay more info	PubMed
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info