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IL1R1 interleukin 1 receptor type 1 [ Homo sapiens (human) ]

Gene ID: 3554, updated on 13-Jan-2019

Summary

Official Symbol
IL1R1provided by HGNC
Official Full Name
interleukin 1 receptor type 1provided by HGNC
Primary source
HGNC:HGNC:5993
See related
Ensembl:ENSG00000115594 MIM:147810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P80; IL1R; IL1RA; CD121A; D2S1473; IL-1R-alpha
Summary
This gene encodes a cytokine receptor that belongs to the interleukin-1 receptor family. The encoded protein is a receptor for interleukin-1 alpha, interleukin-1 beta, and interleukin-1 receptor antagonist. It is an important mediator involved in many cytokine-induced immune and inflammatory responses. This gene is located in a cluster of related cytokine receptor genes on chromosome 2q12. [provided by RefSeq, Dec 2013]
Expression
Ubiquitous expression in gall bladder (RPKM 42.4), placenta (RPKM 40.4) and 24 other tissues See more
Orthologs

Genomic context

See IL1R1 in Genome Data Viewer
Location:
2q11.2-q12.1
Exon count:
21
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (102069638..102179874)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (102686836..102796334)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene interleukin 1 receptor type 2 Neighboring gene uncharacterized LOC107985926 Neighboring gene Sharpr-MPRA regulatory regions 1871 and 11985 Neighboring gene interleukin 1 receptor like 2 Neighboring gene family with sequence similarity 183 member D, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling.
NHGRI GWA Catalog
Genetic Loci Associated with Circulating Levels of Very Long-Chain Saturated Fatty Acids.
NHGRI GWA Catalog
Genome-wide association study to identify genetic determinants of severe asthma.
NHGRI GWA Catalog
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
NHGRI GWA Catalog
Multiethnic meta-analysis of genome-wide association studies in >100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of IL-1RA in uninfected mononuclear cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Amoebiasis, organism-specific biosystem (from KEGG)
    Amoebiasis, organism-specific biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Amoebiasis, conserved biosystem (from KEGG)
    Amoebiasis, conserved biosystemEntamoeba histolytica, an extracellular protozoan parasite is a human pathogen that invades the intestinal epithelium. Infection occurs on ingestion of contaminated water and food. The pathogenesis o...
  • Apoptosis Modulation and Signaling, organism-specific biosystem (from WikiPathways)
    Apoptosis Modulation and Signaling, organism-specific biosystemApoptosis, or cell death program, can be activated by various mechanisms within the extrinsic and the intrinsic pathway. While activation of cell death receptors leads to the engagement of the extrin...
  • Cytokine Signaling in Immune system, organism-specific biosystem (from REACTOME)
    Cytokine Signaling in Immune system, organism-specific biosystemCytokines are small proteins that regulate and mediate immunity, inflammation, and hematopoiesis. They are secreted in response to immune stimuli, and usually act briefly, locally, at very low concen...
  • Cytokine-cytokine receptor interaction, organism-specific biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, organism-specific biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Cytokine-cytokine receptor interaction, conserved biosystem (from KEGG)
    Cytokine-cytokine receptor interaction, conserved biosystemCytokines are soluble extracellular proteins or glycoproteins that are crucial intercellular regulators and mobilizers of cells engaged in innate as well as adaptive inflammatory host defenses, cell ...
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • HTLV-I infection, organism-specific biosystem (from KEGG)
    HTLV-I infection, organism-specific biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • HTLV-I infection, conserved biosystem (from KEGG)
    HTLV-I infection, conserved biosystemHuman T-lymphotropic virus type 1 (HTLV-1) is a pathogenic retrovirus that is associated with adult T-cell leukemia/lymphoma (ATL). It is also strongly implicated in non-neoplastic chronic inflammato...
  • Hematopoietic cell lineage, organism-specific biosystem (from KEGG)
    Hematopoietic cell lineage, organism-specific biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hematopoietic cell lineage, conserved biosystem (from KEGG)
    Hematopoietic cell lineage, conserved biosystemBlood-cell development progresses from a hematopoietic stem cell (HSC), which can undergo either self-renewal or differentiation into a multilineage committed progenitor cell: a common lymphoid proge...
  • Hypertrophy Model, organism-specific biosystem (from WikiPathways)
    Hypertrophy Model, organism-specific biosystem
    Hypertrophy Model
  • IL-1 signaling pathway, organism-specific biosystem (from WikiPathways)
    IL-1 signaling pathway, organism-specific biosystemThe IL-1 family of cytokines currently consists of 11 members which are encoded by distinct genes and includes IL-1?, IL-1?, and the IL-1 Receptor antagonist (IL-1RA). The major role of IL-1 type cyt...
  • IL1 and megakaryocytes in obesity, organism-specific biosystem (from WikiPathways)
    IL1 and megakaryocytes in obesity, organism-specific biosystemSchematic of the effects of interleukin (IL)1-beta/IL1R1 on megakaryocyte and platelet function. A high fat diet will cause megakaryocytes to produce platelets with an increase in both inflammatory a...
  • IL1-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL1-mediated signaling events, organism-specific biosystem
    IL1-mediated signaling events
  • IL12-mediated signaling events, organism-specific biosystem (from Pathway Interaction Database)
    IL12-mediated signaling events, organism-specific biosystem
    IL12-mediated signaling events
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Integrated Pancreatic Cancer Pathway, organism-specific biosystem (from WikiPathways)
    Integrated Pancreatic Cancer Pathway, organism-specific biosystemAn integrated pathway model which displays the protein-protein interactions (PPIs) among the relevant proteins for pancreatic cancer. This pathway is a collection of different mechanistic protein pat...
  • Interleukin-1 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-1 signaling, organism-specific biosystemInterleukin 1 (IL1) signals via Interleukin 1 receptor 1 (IL1R1), the only signaling-capable IL1 receptor. This is a single chain type 1 transmembrane protein comprising an extracellular ligand bindi...
  • Interleukin-10 signaling, organism-specific biosystem (from REACTOME)
    Interleukin-10 signaling, organism-specific biosystemInterleukin-10 (IL10) was originally described as a factor named cytokine synthesis inhibitory factor that inhibited T-helper (Th) 1 activation and Th1 cytokine production (Fiorentino et al. 1989). ...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Monoamine Transport, organism-specific biosystem (from WikiPathways)
    Monoamine Transport, organism-specific biosystem
    Monoamine Transport
  • NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
    NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • NF-kappa B signaling pathway, conserved biosystem (from KEGG)
    NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
  • Osteoclast differentiation, organism-specific biosystem (from KEGG)
    Osteoclast differentiation, organism-specific biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Osteoclast differentiation, conserved biosystem (from KEGG)
    Osteoclast differentiation, conserved biosystemThe osteoclasts, multinucleared cells originating from the hematopoietic monocyte-macrophage lineage, are responsible for bone resorption. Osteoclastogenesis is mainly regulated by signaling pathways...
  • Serotonin Transporter Activity, organism-specific biosystem (from WikiPathways)
    Serotonin Transporter Activity, organism-specific biosystem
    Serotonin Transporter Activity
  • Signaling by Interleukins, organism-specific biosystem (from REACTOME)
    Signaling by Interleukins, organism-specific biosystemInterleukins are low molecular weight proteins that bind to cell surface receptors and act in an autocrine and/or paracrine fashion. They were first identified as factors produced by leukocytes but a...
  • Spinal Cord Injury, organism-specific biosystem (from WikiPathways)
    Spinal Cord Injury, organism-specific biosystemThis pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that...
  • Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystem (from WikiPathways)
    Structural Pathway of Interleukin 1 (IL-1), organism-specific biosystemPathway published in http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003470 IL-1 signaling pathway reconstructed by combining related pathways and information from the litera...
  • Th17 cell differentiation, organism-specific biosystem (from KEGG)
    Th17 cell differentiation, organism-specific biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...
  • Th17 cell differentiation, conserved biosystem (from KEGG)
    Th17 cell differentiation, conserved biosystemInterleukin (IL)-17-producing helper T (Th17) cells serve as a subset of CD4+ T cells involved in epithelial cell- and neutrophil mediated immune responses against extracellular microbes and in the p...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
interleukin-1 binding IEA
Inferred from Electronic Annotation
more info
 
interleukin-1 receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
interleukin-1, type I, activating receptor activity IEA
Inferred from Electronic Annotation
more info
 
platelet-derived growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protease binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
interleukin-1 receptor type 1
Names
CD121 antigen-like family member A
IL-1R-1
IL-1RT-1
IL-1RT1
interleukin 1 receptor alpha, type I
interleukin-1 receptor alpha
interleukin-1 receptor type I

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000877.4NP_000868.1  interleukin-1 receptor type 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_000868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, AL548240, BE144272, BQ021163, HY092388, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Related
    ENSP00000386380.1, ENST00000410023.5
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  2. NM_001288706.1NP_001275635.1  interleukin-1 receptor type 1 isoform 2 precursor

    Status: REVIEWED

    Source sequence(s)
    AK314433, AL548240, BE144272, BQ021163, DA861783, M27492
    Consensus CDS
    CCDS74547.1
    UniProtKB/Swiss-Prot
    P14778
    UniProtKB/TrEMBL
    B8ZZW4
    Related
    ENSP00000386776.1, ENST00000409929.5
    Conserved Domains (5) summary
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    PHA02785
    Location:3320
    PHA02785; IL-beta-binding protein; Provisional
    smart00255
    Location:380509
    TIR; Toll - interleukin 1 - resistance
    cl11960
    Location:226327
    Ig; Immunoglobulin domain
  3. NM_001320978.1NP_001307907.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC007271, AK314433, CB240976, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  4. NM_001320980.1NP_001307909.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, AU136426, CB240976, DB226934, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  5. NM_001320981.1NP_001307910.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, BX472731, CB240976, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  6. NM_001320982.1NP_001307911.1  interleukin-1 receptor type 1 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AC007271, CB240976, DA333942, M27492
    Consensus CDS
    CCDS2055.1
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  7. NM_001320983.1NP_001307912.1  interleukin-1 receptor type 1 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013913, CD014140, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    cd05757
    Location:175
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00255
    Location:240396
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:90184
    IG_like; Immunoglobulin like
    cl11960
    Location:82183
    Ig; Immunoglobulin domain
  8. NM_001320984.1NP_001307913.1  interleukin-1 receptor type 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013912, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (3) summary
    smart00255
    Location:201357
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:51145
    IG_like; Immunoglobulin like
    cl11960
    Location:136
    Ig; Immunoglobulin domain
  9. NM_001320985.1NP_001307914.1  interleukin-1 receptor type 1 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: The 5' UTR variation has not been determined for this transcript.
    Source sequence(s)
    AC007271, CB240976, CD013913, M27492, X16896
    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (2) summary
    smart00255
    Location:149305
    TIR; Toll - interleukin 1 - resistance
    smart00410
    Location:193
    IG_like; Immunoglobulin like
  10. NM_001320986.1NP_001307915.1  interleukin-1 receptor type 1 isoform 6 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) is transcribed from a downstream promoter compared to variant 2.
    Source sequence(s)
    AU136426, CA421991, DB226934
    Related
    ENSP00000386555.1, ENST00000409589.5
    Conserved Domains (3) summary
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    smart00410
    Location:43103
    IG_like; Immunoglobulin like
    cl11960
    Location:128162
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    102069638..102179874
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011511117.1XP_011509419.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509419.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  2. XM_011511115.2XP_011509417.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509417.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  3. XM_011511116.1XP_011509418.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509418.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  4. XM_017003989.1XP_016859478.1  interleukin-1 receptor type 1 isoform X1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  5. XM_005263930.4XP_005263987.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263987.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  6. XM_005263934.4XP_005263991.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_005263991.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
  7. XM_011511118.2XP_011509420.1  interleukin-1 receptor type 1 isoform X1

    See identical proteins and their annotated locations for XP_011509420.1

    UniProtKB/Swiss-Prot
    P14778
    Conserved Domains (4) summary
    smart00255
    Location:384540
    TIR; Toll - interleukin 1 - resistance
    smart00409
    Location:234328
    IG; Immunoglobulin
    cd05756
    Location:24113
    Ig1_IL1R_like; First immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
    cd05757
    Location:128219
    Ig2_IL1R_like; Second immunoglobulin (Ig)-like domain of interleukin-1 receptor (IL1R) and similar proteins
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