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BubR1 Bub1-related kinase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35522, updated on 4-Dec-2018

Summary

Official Symbol
BubR1provided by FlyBase
Official Full Name
Bub1-related kinaseprovided by FlyBase
Primary source
FLYBASE:FBgn0263855
Locus tag
Dmel_CG7838
Gene type
protein coding
RNA name
Bub1-related kinase
RefSeq status
REVIEWED
Organism
Drosophila melanogaster (old-lineage: Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
31/13; BcDNA:LD23835; bub1; Bub1; BUB1; bubr1; bubR1; BUBR1; CG 7838; CG7838; dBUB1; Dmbub1; DmBUB1; DmBubRI; Dmel\CG7838; l(2)k03113; l(2)k06109; mcl(2)Z1525

Genomic context

See BubR1 in Genome Data Viewer
Location:
42A5-42A6; 2-55 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.13 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (5969099..5974385, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (1856604..1861890, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene maleless Neighboring gene Src oncogene at 42A

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
female meiosis sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
male meiosis sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
meiotic sister chromatid cohesion, centromeric IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
meiotic sister chromatid cohesion, centromeric IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly checkpoint IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitotic spindle assembly checkpoint IDA
Inferred from Direct Assay
more info
PubMed 
mitotic spindle assembly checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic spindle assembly checkpoint TAS
Traceable Author Statement
more info
PubMed 
positive regulation of chromatin silencing IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
protein phosphorylation NAS
Non-traceable Author Statement
more info
PubMed 
regulation of exit from mitosis IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of exit from mitosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of mitotic sister chromatid separation IMP
Inferred from Mutant Phenotype
more info
PubMed 
synaptonemal complex organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
condensed chromosome outer kinetochore NAS
Non-traceable Author Statement
more info
PubMed 
condensed nuclear chromosome kinetochore IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore IDA
Inferred from Direct Assay
more info
PubMed 
kinetochore TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Bub1-related kinase
Names
BubR1-PA
CG7838-PA
bub related one
NP_477382.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    5969099..5974385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_058034.4NP_477382.1  Bub1-related kinase [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477382.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1Z6I7
    Related
    FBpp0085368, FBtr0086032
    Conserved Domains (2) summary
    cd13981
    Location:11741458
    STKc_Bub1_BubR1; Catalytic domain of the Serine/Threonine kinases, Spindle assembly checkpoint proteins Bub1 and BubR1
    pfam08311
    Location:38159
    Mad3_BUB1_I; Mad3/BUB1 homology region 1
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