IKBKB inhibitor of nuclear factor kappa B kinase subunit beta [Homo sapiens (human)] - Gene

Summary

Official Symbol: IKBKBprovided by HGNC
Official Full Name: inhibitor of nuclear factor kappa B kinase subunit betaprovided by HGNC
Primary source: HGNC:HGNC:5960
See related: Ensembl:ENSG00000104365 MIM:603258
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: IKK2; IKKB; IMD15; IMD15A; IMD15B; NFKBIKB; IKK-beta
Summary: The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Expression: Ubiquitous expression in spleen (RPKM 14.6), lymph node (RPKM 12.4) and 25 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 8p11.21

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
109.20200228	current	GRCh38.p13 (GCF_000001405.39)	8	NC_000008.11 (42270727..42332653)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (42128820..42190171)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data indicate that the IKKs restrict infection but HCMV targets their signaling to modulate the cellular inflammatory environment.
Title: The IκB Kinases Restrict Human Cytomegalovirus Infection.
Our data demonstrated that co-targeting EGFR and IKKbeta with Gefitinib and IKKbeta inhibitors could provide a potential novel therapy for head and neck squamous cell cancer.
Title: Co-targeting EGFR and IKKβ/NF-κB signalling pathways in head and neck squamous cell carcinoma: a potential novel therapy for head and neck squamous cell cancer.
Study shows that IKKbeta promotes adipogenesis but inhibits osteogenesis in murine and human mesenchymal stem cells (MSCs) through an NF-kappaB-independent mechanism. IKKbeta is a beta-catenin kinase that phosphorylates the degron motif of beta-catenin to prime it for beta-TrCP-mediated ubiquitination and degradation, thereby regulating MSC fate.
Title: IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.
in the absence of stimulus, IKK-EDC4 promoted destabilization of pro-inflammatory cytokines and regulators of apoptosis.
Title: The IκB kinase complex is a regulator of mRNA stability.
These findings identify a previously unrecognized role of SKP2 in NF-kappaB activation by which SKP2 acts as a secondary receptor to assist IKKbeta delivery to autophagosomes for degradation in a p62-dependent manner.
Title: SKP2 attenuates NF-κB signaling by mediating IKKβ degradation through autophagy.
IKK2 promotes the gastric cancer cell proliferation and inhibits their apoptosis.
Title: Inhibition of IκB Kinase 2 Attenuated the Proliferation and Induced Apoptosis of Gastric Cancer.
Gain-of-function IKBKB mutation causes human combined immune deficiency.
Title: Gain-of-function <i>IKBKB</i> mutation causes human combined immune deficiency.
K63-linked ubiquitination occurs in other kinases at sites homologous to K147 in IKKbeta, including K578 in BRAF V600E, which serves as an oncogenic driver in melanoma and other cancers.
Title: Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation.
Depletion of human IKK1, IKK2 or IKK1/2 leads to strongly impaired NF-kappaB activation. Only IKK1/2 double-deficient cells are sensitized to TNF-alpha induced cell death. Cell death is mediated independently on NF-kappaB via RIPK1.
Title: IKK1/2 protect human cells from TNF-mediated RIPK1-dependent apoptosis in an NF-κB-independent manner.
data in the current study have revealed a novel role for IKKbeta in negatively regulating GADD45alpha protein stability and the contribution of p53-dependent IKKbeta reduction to mediating cancer cell apoptosis.
Title: Transcriptional repression of IKKβ by p53 in arsenite-induced GADD45α accumulation and apoptosis.

Submit: New GeneRIF Correction See all GeneRIFs (236)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Immunodeficiency 15 MedGen: C3810043 OMIM: 615592 GeneReviews: Not available	Compare labs
IMMUNODEFICIENCY 15A MedGen: C4748694 OMIM: 618204 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 JRFL (gp120) degrades IkappaBeta Kinases (IkB) in RPE cells	PubMed
	env	HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs)	PubMed
Nef	nef	HIV-1 Nef induces phosphorylation of IKBKB (IKK2)	PubMed
	nef	HIV-1 and SIVcpz Nef proteins enhance TNF-alpha, IKK-beta, and RelA/p65-induced NF-kappaB activation in 293T cells	PubMed
	nef	HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1	PubMed
	nef	The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages	PubMed
	nef	HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members	PubMed
Tat	tat	HIV-1 Tat induces phosphorylation of IKBKB (IKK2) in CRT-MG human astroglioma cells	PubMed
	tat	Curcumin and celastrol attenuate HIV-1 Tat-induced p65/NFKappaB phosphorylation and IKK phosphorylation	PubMed
	tat	HIV-1 Tat-mediated upregulation of ICAM-1 expression involves MEK1/2, JNK, and p38 MAPK proteins and downstream IKK2/NF-kappaB signaling pathways	PubMed
	tat	Nox2 is involved in HIV-1 Tat-induced NADPH oxidase p65 and IKK phosphorylation	PubMed
Vpr	vpr	HIV-1 Vpr requires CHUK (IKKa) or IKBKB (IKKb) to induce G2/M arrest in HeLa cells as shown through siRNA knockdown of each	PubMed
	vpr	Activation of TAK1 by HIV-1 Vpr leads to increased levels of phosphorylated IKK-beta and MKK7 in cells	PubMed
Vpu	vpu	Most HIV-1 and primate lentiviral Vpu proteins inhibit IKK-beta-induced NF-kappaB activation except HIV-1 group N Vpu proteins	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11S2921 (e-PCR)
- UniSTS:152074

RH104595 (e-PCR)
- UniSTS:99861

RH75091 (e-PCR)
- UniSTS:86861

L18426 (e-PCR)
- UniSTS:34648

D10S16 (e-PCR)
- UniSTS:155756

STS-N21119 (e-PCR)
- UniSTS:25813

D5S1597E (e-PCR)
- UniSTS:151019

Homology

Homologs of the IKBKB gene: The IKBKB gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 316 organisms have orthologs with human gene IKBKB
Orthologs

Clone Names

FLJ33771, FLJ36218, FLJ38368, FLJ40509, MGC131801

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
ATP binding	IEA Inferred from Electronic Annotation more info
contributes_to IkappaB kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
IkappaB kinase activity	TAS Traceable Author Statement more info	PubMed
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
protein serine/threonine kinase activity	EXP Inferred from Experiment more info	PubMed
protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
protein serine/threonine kinase activity	TAS Traceable Author Statement more info
scaffold protein binding	IDA Inferred from Direct Assay more info	PubMed
transferrin receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
Fc-epsilon receptor signaling pathway	TAS Traceable Author Statement more info
I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
I-kappaB kinase/NF-kappaB signaling	TAS Traceable Author Statement more info	PubMed
I-kappaB phosphorylation	IEA Inferred from Electronic Annotation more info
MyD88-independent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
T cell receptor signaling pathway	TAS Traceable Author Statement more info
TRIF-dependent toll-like receptor signaling pathway	TAS Traceable Author Statement more info
antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent	TAS Traceable Author Statement more info
cellular response to tumor necrosis factor	IDA Inferred from Direct Assay more info	PubMed
cortical actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
inflammatory response	TAS Traceable Author Statement more info	PubMed
innate immune response	TAS Traceable Author Statement more info	PubMed
interleukin-1-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
interleukin-1-mediated signaling pathway	TAS Traceable Author Statement more info
negative regulation of apoptotic process	TAS Traceable Author Statement more info
negative regulation of bicellular tight junction assembly	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of myosin-light-chain-phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
peptidyl-serine phosphorylation	IDA Inferred from Direct Assay more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	IMP Inferred from Mutant Phenotype more info	PubMed
positive regulation of I-kappaB kinase/NF-kappaB signaling	TAS Traceable Author Statement more info
positive regulation of NF-kappaB transcription factor activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
positive regulation of NF-kappaB transcription factor activity	TAS Traceable Author Statement more info	PubMed
positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
positive regulation of transcription, DNA-templated	NAS Non-traceable Author Statement more info	PubMed
protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
protein phosphorylation	NAS Non-traceable Author Statement more info	PubMed
regulation of establishment of endothelial barrier	IMP Inferred from Mutant Phenotype more info	PubMed
regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
response to virus	TAS Traceable Author Statement more info	PubMed
stimulatory C-type lectin receptor signaling pathway	TAS Traceable Author Statement more info
stress-activated MAPK cascade	TAS Traceable Author Statement more info
tumor necrosis factor-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
tumor necrosis factor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
viral process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
CD40 receptor complex	ISS Inferred from Sequence or Structural Similarity more info
IkappaB kinase complex	IBA Inferred from Biological aspect of Ancestor more info	PubMed
IkappaB kinase complex	TAS Traceable Author Statement more info	PubMed
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytoplasmic side of plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
cytosol	IDA Inferred from Direct Assay more info
cytosol	TAS Traceable Author Statement more info
membrane raft	IEA Inferred from Electronic Annotation more info
nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: inhibitor of nuclear factor kappa-B kinase subunit beta

Names: I-kappa-B kinase 2; I-kappa-B-kinase beta; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; nuclear factor NF-kappa-B inhibitor kinase beta

NP_001177649.1

EC 2.7.11.10

NP_001229707.1

EC 2.7.11.10

NP_001547.1

EC 2.7.11.10

XP_005273547.1

EC 2.7.11.10

XP_005273548.1

EC 2.7.11.10

XP_005273549.1

EC 2.7.11.10

XP_005273550.1

EC 2.7.11.10

XP_005273551.1

EC 2.7.11.10

XP_005273552.1

EC 2.7.11.10

XP_005273553.1

EC 2.7.11.10

XP_005273555.1

EC 2.7.11.10

XP_011542819.1

EC 2.7.11.10

XP_011542820.1

EC 2.7.11.10

XP_011542821.1

EC 2.7.11.10

XP_011542822.1

EC 2.7.11.10

XP_011542823.1

EC 2.7.11.10

XP_011542824.1

EC 2.7.11.10

XP_016868885.1

EC 2.7.11.10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_041793.1 RefSeqGene

Range

5001..66159

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1241

mRNA and Protein(s)

NM_001190720.2 → NP_001177649.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an exon in the 5' region, resulting in an upstream AUG start codon, as compared to variant 1. The resulting isoform (2) is slightly shorter and has a different N-terminus, as compared to isoform 1.

Source sequence(s)

AC083973, AK302723, AK303528, DA043516

Consensus CDS

CCDS55228.1

UniProtKB/Swiss-Prot

O14920

Related

ENSP00000404920.3, ENST00000416505.6

Conserved Domains (3) summary

smart00220
Location:34 → 288

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:33 → 307

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam12179
Location:706 → 740

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain
NM_001242778.2 → NP_001229707.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 5

See identical proteins and their annotated locations for NP_001229707.1

Status: REVIEWED

Description

Transcript Variant: This variant (7) lacks an alternate exon in the 5' coding region and uses an alternate start codon, compared to variant 1. The resulting isoform (5) has a shorter and distinct N-terminus, compared to variant 1.

Source sequence(s)

AC083973, AI379342, AK303528, DA159382

UniProtKB/Swiss-Prot

O14920

Conserved Domains (3) summary

smart00220
Location:8 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12179
Location:649 → 683

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

cl21453
Location:8 → 250

PKc_like; Protein Kinases, catalytic domain
NM_001556.3 → NP_001547.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform 1

See identical proteins and their annotated locations for NP_001547.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AF080158, AI379342, BC090865, DA709000

Consensus CDS

CCDS6128.1

UniProtKB/Swiss-Prot

O14920

Related

ENSP00000430684.1, ENST00000520810.6

Conserved Domains (3) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam12179
Location:708 → 742

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

RNA

NR_033818.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (5) has an additional segment in the CDS, resulting in reading frame-shift and earlier translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.

Source sequence(s)

AC083973, AI379342, BC090865, DA159382

Related

ENST00000342222.6
NR_033819.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (6) lacks an exon in the 3' CDS, resulting in reading frame-shift and earlier translation termination, as compared to variant 1. The transcript is a nonsense-mediated mRNA decay candidate.

Source sequence(s)

AC083973, AI379342, AK290952, BC108694, DA105584

Related

ENST00000629753.1
NR_040009.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (8) uses an alternate splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC083973, AI379342, BC144080, DA159382

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p13 Primary Assembly

Range

42270727..42332653

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005273491.5 → XP_005273548.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

See identical proteins and their annotated locations for XP_005273548.1

Conserved Domains (3) summary

smart00220
Location:8 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam13900
Location:726 → 746

GVQW; Putative domain of unknown function

cl21453
Location:8 → 250

PKc_like; Protein Kinases, catalytic domain
XM_005273496.4 → XP_005273553.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8

See identical proteins and their annotated locations for XP_005273553.1

Conserved Domains (4) summary

pfam12179
Location:498 → 525

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:575 → 595

GVQW; Putative domain of unknown function

cl00155
Location:90 → 146

UBQ; Ubiquitin-like proteins

cl21453
Location:14 → 99

PKc_like; Protein Kinases, catalytic domain
XM_005273493.4 → XP_005273550.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X6

Conserved Domains (4) summary

smart00220
Location:18 → 185

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12179
Location:603 → 630

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:680 → 700

GVQW; Putative domain of unknown function

cl21453
Location:25 → 204

PKc_like; Protein Kinases, catalytic domain
XM_005273498.4 → XP_005273555.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8

See identical proteins and their annotated locations for XP_005273555.1

Conserved Domains (4) summary

pfam12179
Location:498 → 525

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:575 → 595

GVQW; Putative domain of unknown function

cl00155
Location:90 → 146

UBQ; Ubiquitin-like proteins

cl21453
Location:14 → 99

PKc_like; Protein Kinases, catalytic domain
XM_011544518.2 → XP_011542820.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X2

Conserved Domains (5) summary

smart00220
Location:15 → 153

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12179
Location:658 → 685

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:735 → 755

GVQW; Putative domain of unknown function

cl00155
Location:250 → 306

UBQ; Ubiquitin-like proteins

cl21453
Location:20 → 259

PKc_like; Protein Kinases, catalytic domain
XM_005273492.4 → XP_005273549.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X5

Conserved Domains (2) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
XM_005273490.3 → XP_005273547.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

See identical proteins and their annotated locations for XP_005273547.1

Conserved Domains (3) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam13900
Location:785 → 805

GVQW; Putative domain of unknown function
XM_005273494.3 → XP_005273551.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X7

Related

ENSP00000428186.1, ENST00000521661.5

Conserved Domains (1) summary

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta
XM_017013396.1 → XP_016868885.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9

Conserved Domains (4) summary

pfam12179
Location:429 → 456

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:506 → 526

GVQW; Putative domain of unknown function

cl00155
Location:21 → 77

UBQ; Ubiquitin-like proteins

cl21453
Location:1 → 30

PKc_like; Protein Kinases, catalytic domain
XM_011544521.2 → XP_011542823.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8

See identical proteins and their annotated locations for XP_011542823.1

Conserved Domains (4) summary

pfam12179
Location:498 → 525

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:575 → 595

GVQW; Putative domain of unknown function

cl00155
Location:90 → 146

UBQ; Ubiquitin-like proteins

cl21453
Location:14 → 99

PKc_like; Protein Kinases, catalytic domain
XM_011544522.2 → XP_011542824.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X9

Conserved Domains (4) summary

pfam12179
Location:429 → 456

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:506 → 526

GVQW; Putative domain of unknown function

cl00155
Location:21 → 77

UBQ; Ubiquitin-like proteins

cl21453
Location:1 → 30

PKc_like; Protein Kinases, catalytic domain
XM_005273495.2 → XP_005273552.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X8

See identical proteins and their annotated locations for XP_005273552.1

Conserved Domains (4) summary

pfam12179
Location:498 → 525

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:575 → 595

GVQW; Putative domain of unknown function

cl00155
Location:90 → 146

UBQ; Ubiquitin-like proteins

cl21453
Location:14 → 99

PKc_like; Protein Kinases, catalytic domain
XM_011544517.2 → XP_011542819.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X1

See identical proteins and their annotated locations for XP_011542819.1

Conserved Domains (3) summary

smart00220
Location:15 → 290

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14038
Location:20 → 309

STKc_IKK_beta; Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta

pfam13900
Location:785 → 805

GVQW; Putative domain of unknown function
XM_011544520.2 → XP_011542822.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X4

Conserved Domains (4) summary

smart00220
Location:38 → 205

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam12179
Location:623 → 650

IKKbetaNEMObind; I-kappa-kinase-beta NEMO binding domain

pfam13900
Location:700 → 720

GVQW; Putative domain of unknown function

cl21453
Location:45 → 224

PKc_like; Protein Kinases, catalytic domain
XM_011544519.2 → XP_011542821.1 inhibitor of nuclear factor kappa-B kinase subunit beta isoform X3

See identical proteins and their annotated locations for XP_011542821.1

Conserved Domains (3) summary

smart00220
Location:8 → 231

S_TKc; Serine/Threonine protein kinases, catalytic domain

pfam13900
Location:726 → 746

GVQW; Putative domain of unknown function

cl21453
Location:8 → 250

PKc_like; Protein Kinases, catalytic domain

RNA

XR_949402.3 RNA Sequence
XR_001745530.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001190721.1: Suppressed sequence

Description

NM_001190721.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support this transcript.
NM_001190722.1: Suppressed sequence

Description

NM_001190722.1: This RefSeq was permanently suppressed because there is not sufficient data to support this transcript.