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eEF2 eukaryotic translation elongation factor 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35422, updated on 2-Nov-2024

Summary

Official Symbol
eEF2provided by FlyBase
Official Full Name
eukaryotic translation elongation factor 2provided by FlyBase
Primary source
FLYBASE:FBgn0000559
Locus tag
Dmel_CG2238
See related
AllianceGenome:FB:FBgn0000559
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-EST:Liang-1.44; CG2238; chr2L:21668915..21669164; clone 1.44; Dmel\CG2238; EF-2; EF-2b; eF2; Ef2; EF2; ef2b; Ef2b; Ef2B; EF2b; EF2B
Summary
Predicted to enable GTPase activity; ribosome binding activity; and translation elongation factor activity. Predicted to be involved in translational elongation. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol. Is expressed in several structures, including adult head; adult heart; embryonic/larval mushroom body; embryonic/larval optic lobe; and imaginal disc. Human ortholog(s) of this gene implicated in glaucoma; spinocerebellar ataxia type 26; and stomach cancer. Orthologous to human EEF2 (eukaryotic translation elongation factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See eEF2 in Genome Data Viewer
Location:
39E7-39E7; 2-54 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21677913..21682164, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21677913..21682164, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR46066 Neighboring gene Cullin 2 Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA 254 Neighboring gene no long nerve cord Neighboring gene steppke

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables translation elongation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in translational elongation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
eukaryotic translation elongation factor 2
Names
CG2238-PA
CG2238-PC
CG2238-PD
ELONGATION FACTOR 2
eEF2-PA
eEF2-PC
eEF2-PD
elongation factor 2b
eukaryotic translation elongation factor 2b

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21677913..21682164 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_165394.3NP_724357.2  eukaryotic translation elongation factor 2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724357.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A023GPJ5, P13060, Q9I7H2, Q9V9R0
    Conserved Domains (1) summary
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional
  2. NM_165395.2NP_724358.2  eukaryotic translation elongation factor 2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724358.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A023GPJ5, P13060, Q9I7H2, Q9V9R0
    Conserved Domains (1) summary
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional
  3. NM_080366.3NP_525105.2  eukaryotic translation elongation factor 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_525105.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A023GPJ5, P13060, Q9I7H2, Q9V9R0
    Related
    FBpp0085265
    Conserved Domains (1) summary
    PTZ00416
    Location:1844
    PTZ00416; elongation factor 2; Provisional