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Dap160 Dynamin associated protein 160 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35378, updated on 12-Aug-2026
Official Symbol
Dap160provided by FlyBase
Official Full Name
Dynamin associated protein 160provided by FlyBase
Primary source
FLYBASE:FBgn0023388
Locus tag
Dmel_CG1099
See related
AllianceGenome:FB:FBgn0023388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1099; DAP-160; dap160; DAP160; Dap160/intersectin; Dmel\CG1099; noncoding_4110; p160
Summary
Enables protein kinase activator activity. Involved in several processes, including negative regulation of Notch signaling pathway; positive regulation of neuroblast proliferation; and synaptic vesicle endocytosis. Located in apical cortex and synaptic vesicle. Colocalizes with presynaptic membrane. Is expressed in several structures, including adult heart; embryonic foregut sensory structure; embryonic head epidermis; ganglia; and head. Used to study intellectual disability. Orthologous to several human genes including ITSN2 (intersectin 2). [provided by Alliance of Genome Resources, Jul 2025]
Orthologs
all
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Try the new Transcripts and proteins table
See Dap160 in Genome Data Viewer
Location:
39A3-39A4; 2-54 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21134439..21142347, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21134439..21142347, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43809 Neighboring gene long non-coding RNA:CR44056 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Na[+]/H[+] hydrogen exchanger 2 Neighboring gene ncRNA Neighboring gene porthos Neighboring gene deadlock

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Intersectin enhances huntingtin aggregation and neurodegeneration through activation of c-Jun-NH2-terminal kinase. Scappini E, et al. Hum Mol Genet, 2007 Aug 1. PMID 17550941
  2. Molecular links between endocytosis and the actin cytoskeleton. Qualmann B, et al. J Cell Biol, 2000 Sep 4. PMID 10974009, Free PMC Article
  3. Membrane Charge Directs the Outcome of F-BAR Domain Lipid Binding and Autoregulation. Kelley CF, et al. Cell Rep, 2015 Dec 22. PMID 26686642, Free PMC Article
  4. Chloroplast division: a work of ARTEMIS. Osteryoung KW. Curr Biol, 2002 Dec 23. PMID 12498703
  5. Functional diversity in the dynamin family. van der Bliek AM. Trends Cell Biol, 1999 Mar. PMID 10201074

See all (121) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dap160 is involved in the regulation of endocytosis and exocytosis in synapses.
    Title: An Endocytic Scaffolding Protein together with Synapsin Regulates Synaptic Vesicle Clustering in the Drosophila Neuromuscular Junction.
  2. Findings imply that restoring the level of any one of these genes dap160/itsn1, synj/synj1, and nla/dscr1 may reduce endocytic defects seen in DS.
    Title: Upregulation of three Drosophila homologs of human chromosome 21 genes alters synaptic function: implications for Down syndrome.
  3. Dap160 positively regulates aPKC activity and localization to promote neuroblast cell polarity and cell cycle progression.
    Title: Dap160/intersectin binds and activates aPKC to regulate cell polarity and cell cycle progression.
  4. Dap160 scaffolds both endocytic machinery and essential synaptic signaling systems to the periactive zone to coordinately control structural and functional synapse development.
    Title: Dap160/intersectin scaffolds the periactive zone to achieve high-fidelity endocytosis and normal synaptic growth.
  5. Dap160, like dynamin, is involved in synaptic vesicle retrieval at active and periactive zones.
    Title: Dap160/intersectin acts as a stabilizing scaffold required for synaptic development and vesicle endocytosis.
  6. Dap160 controls synaptic vesicle membrane retrieval and synapse development.
    Title: Eps15 and Dap160 control synaptic vesicle membrane retrieval and synapse development.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in bulk synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in clathrin-dependent synaptic vesicle endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in clathrin-dependent synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle endocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in intracellular vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
dynamin associated protein 160
Names
CG1099-PA
CG1099-PB
CG1099-PC
CG1099-PD
CG1099-PG
CG1099-PH
Dap160-PA
Dap160-PB
Dap160-PC
Dap160-PD
Dap160-PG
Dap160-PH
Dynamin-associated protein 160 kDa
intersectin

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21134439..21142347 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259189.2 → NP_001246118.1  dynamin associated protein 160, isoform D

    See identical proteins and their annotated locations for NP_001246118.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9ND00, O61618
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:674 → 728
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:779 → 830
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:941 → 998
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:1025 → 1077
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:369 → 570
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:495 → 589
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:432 → 443
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:366 → 467
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001273735.1 → NP_001260664.1  dynamin associated protein 160, isoform H

    See identical proteins and their annotated locations for NP_001260664.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDC7, O61639
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:678 → 732
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:783 → 834
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:862 → 919
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:946 → 998
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:373 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:499 → 593
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:436 → 447
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:370 → 471
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_001273734.1 → NP_001260663.1  dynamin associated protein 160, isoform G

    See identical proteins and their annotated locations for NP_001260663.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PBF6, O61618
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:678 → 732
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:783 → 834
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:945 → 1002
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:1029 → 1081
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:373 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:499 → 593
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:436 → 447
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:370 → 471
    GBP_C; Guanylate-binding protein, C-terminal domain

  4. NM_057975.4 → NP_477323.1  dynamin associated protein 160, isoform B

    See identical proteins and their annotated locations for NP_477323.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61639, Q8INU2
    Related
    FBpp0081032
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:678 → 732
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:783 → 834
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:862 → 919
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:946 → 998
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:373 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:499 → 593
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:436 → 447
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:370 → 471
    GBP_C; Guanylate-binding protein, C-terminal domain

  5. NM_001169557.2 → NP_001163028.1  dynamin associated protein 160, isoform C

    See identical proteins and their annotated locations for NP_001163028.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JHN1, O61618, Q1WWC9
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:678 → 732
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:783 → 834
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:944 → 1001
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:1028 → 1080
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:373 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:499 → 593
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:436 → 447
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:370 → 471
    GBP_C; Guanylate-binding protein, C-terminal domain

  6. NM_057974.4 → NP_477322.1  dynamin associated protein 160, isoform A

    See identical proteins and their annotated locations for NP_477322.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O61618, Q9VIF7
    Related
    FBpp0081031
    Conserved Domains (10) summary
    smart00027
    Location:184 → 279
    EH; Eps15 homology domain
    cd11836
    Location:678 → 732
    SH3_Intersectin_1; First Src homology 3 domain (or SH3A) of Intersectin
    cd11838
    Location:783 → 834
    SH3_Intersectin_3; Third Src homology 3 domain (or SH3C) of Intersectin
    cd11839
    Location:945 → 1002
    SH3_Intersectin_4; Fourth Src homology 3 domain (or SH3D) of Intersectin
    cd11840
    Location:1029 → 1081
    SH3_Intersectin_5; Fifth Src homology 3 domain (or SH3E) of Intersectin
    cd00052
    Location:195 → 261
    EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
    pfam05010
    Location:373 → 574
    TACC; Transforming acidic coiled-coil-containing protein (TACC)
    pfam07106
    Location:499 → 593
    TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    cd16269
    Location:436 → 447
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:370 → 471
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9ND00 M9ND00
M9PBF6 M9PBF6
M9PDC7 M9PDC7
O61618 O61618
O61639 O61639
Q1WWC9 Q1WWC9
Q8INU2 Q8INU2
Q8T068 Q8T068
Q9VIF7 Q9VIF7

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