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l(2)05287 lethal (2) 05287 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35374, updated on 2-Nov-2024

Summary

Official Symbol
l(2)05287provided by FlyBase
Official Full Name
lethal (2) 05287provided by FlyBase
Primary source
FLYBASE:FBgn0284251
Locus tag
Dmel_CG12050
See related
AllianceGenome:FB:FBgn0284251
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG12050; Dmel\CG12050
Summary
Predicted to enable RNA binding activity. Predicted to be involved in positive regulation of rRNA processing and positive regulation of transcription by RNA polymerase I. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic/larval midgut primordium; larval muscle cell; and mesoderm. Orthologous to human WDR75 (WD repeat domain 75). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

See l(2)05287 in Genome Data Viewer
Location:
39A1-39A2; 2-54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21094966..21102429, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21094966..21102429, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43809 Neighboring gene long non-coding RNA:CR44056 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Na[+]/H[+] hydrogen exchanger 2

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in positive regulation of rRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase I IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase I IEA
Inferred from Electronic Annotation
more info
 
involved_in ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of small-subunit processome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
lethal (2) 05287
Names
CG12050-PB
l(2)05287-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21094966..21102429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136242.4NP_610086.3  lethal (2) 05287 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610086.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95RG7, Q9VIG1
    Conserved Domains (3) summary
    COG2319
    Location:26324
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:205244
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:245544
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...