Tmc4 transmembrane channel-like gene family 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tmc4provided by MGI
Official Full Name: transmembrane channel-like gene family 4provided by MGI
Primary source: MGI:MGI:2669035
See related: Ensembl:ENSMUSG00000019734 AllianceGenome:MGI:2669035
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable mechanosensitive ion channel activity. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Orthologous to human TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in colon adult (RPKM 152.7), large intestine adult (RPKM 107.6) and 11 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7; 7 A1

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (3668753..3680552, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (3665754..3677553, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.
Title: TMC4 is a novel chloride channel involved in high-concentration salt taste sensation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH132704 (e-PCR)
- UniSTS:215987

Homology

Homologs of the Tmc4 gene: The Tmc4 gene is conserved in human, chimpanzee, and dog.
Orthologs from Annotation Pipeline: 384 organisms have orthologs with human gene Tmc4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables mechanosensitive monoatomic ion channel activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transmembrane channel-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181820.3 → NP_861541.2 transmembrane channel-like protein 4

See identical proteins and their annotated locations for NP_861541.2

Status: VALIDATED

Source sequence(s)

AC171680

Consensus CDS

CCDS20723.1

UniProtKB/Swiss-Prot

Q7TQ65

UniProtKB/TrEMBL

F8VQ45

Related

ENSMUSP00000043853.9, ENSMUST00000038743.15

Conserved Domains (2) summary

pfam02714
Location:367 → 435

RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate

pfam07810
Location:462 → 562

TMC; TMC domain