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Tmc4 transmembrane channel-like gene family 4 [ Mus musculus (house mouse) ]

Gene ID: 353499, updated on 30-Apr-2024

Summary

Official Symbol
Tmc4provided by MGI
Official Full Name
transmembrane channel-like gene family 4provided by MGI
Primary source
MGI:MGI:2669035
See related
Ensembl:ENSMUSG00000019734 AllianceGenome:MGI:2669035
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mechanosensitive ion channel activity. Predicted to act upstream of or within ion transport. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Orthologous to human TMC4 (transmembrane channel like 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 152.7), large intestine adult (RPKM 107.6) and 11 other tissues See more
Orthologs
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Genomic context

See Tmc4 in Genome Data Viewer
Location:
7 A1; 7 2.11 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3668790..3680522, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3665754..3677553, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene pre-mRNA processing factor 31 Neighboring gene predicted gene 15927 Neighboring gene STARR-seq mESC enhancer starr_17914 Neighboring gene CCR4-NOT transcription complex, subunit 3 Neighboring gene microRNA 3572 Neighboring gene STARR-positive B cell enhancer ABC_E1077 Neighboring gene leukocyte receptor cluster (LRC) member 1 Neighboring gene membrane bound O-acyltransferase domain containing 7 Neighboring gene tRNA splicing endonuclease subunit 34

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables mechanosensitive monoatomic ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane channel-like protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181820.3NP_861541.2  transmembrane channel-like protein 4

    See identical proteins and their annotated locations for NP_861541.2

    Status: VALIDATED

    Source sequence(s)
    AC171680
    Consensus CDS
    CCDS20723.1
    UniProtKB/Swiss-Prot
    Q7TMJ5, Q7TN62, Q7TQ65, Q8C7J5, Q8CGE2, Q8R1X9
    UniProtKB/TrEMBL
    F8VQ45
    Related
    ENSMUSP00000043853.9, ENSMUST00000038743.15
    Conserved Domains (2) summary
    pfam02714
    Location:367435
    RSN1_7TM; Calcium-dependent channel, 7TM region, putative phosphate
    pfam07810
    Location:462562
    TMC; TMC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3668790..3680522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)