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dia diaphanous [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35340, updated on 26-Aug-2021

Summary

Official Symbol
diaprovided by FlyBase
Official Full Name
diaphanousprovided by FlyBase
Primary source
FLYBASE:FBgn0011202
Locus tag
Dmel_CG1768
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38E.16; CG1768; Dia; DIA; Dias; Dmel\CG1768; l(2)k07135; ms(2)04138
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Genomic context

See dia in Genome Data Viewer
Location:
38E7-38E8; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20758144..20768053)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20758144..20768053)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Female sterile (2) Ketel Neighboring gene Alpha-methylacyl-CoA racemase Neighboring gene Nucleostemin 4 Neighboring gene RHAU helicase Neighboring gene caudal Neighboring gene pomp Neighboring gene varicose

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton reorganization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actomyosin contractile ring assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apical constriction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in assembly of apicomedial cortex actomyosin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellularization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of protein location in cell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiosis I cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in meiosis II cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in melanotic encapsulation of foreign target IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mitotic cytokinesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in open tracheal system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in plasma membrane tubulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pole cell formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of wound healing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in pseudocleavage involved in syncytial blastoderm formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of actomyosin structure organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of embryonic cell shape IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sarcomere organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spindle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in M band IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in Z disc IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with actin filament IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoneme IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in vesicle membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
diaphanous
Names
CG1768-PA
CG1768-PB
CG1768-PC
CG1768-PD
CG1768-PE
dia-PA
dia-PB
dia-PC
dia-PD
dia-PE

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20758144..20768053
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273711.1NP_001260640.1  diaphanous, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48608
    UniProtKB/TrEMBL
    M9PDV1
    Related
    FBpp0307144, FBtr0335145
    Conserved Domains (3) summary
    pfam02181
    Location:601976
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:246446
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:59241
    Drf_GBD; Diaphanous GTPase-binding Domain
  2. NM_057633.5NP_476981.1  diaphanous, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476981.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48608
    UniProtKB/TrEMBL
    M9PDV1
    Related
    FBpp0080940, FBtr0081410
    Conserved Domains (3) summary
    pfam02181
    Location:601976
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:246446
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:59241
    Drf_GBD; Diaphanous GTPase-binding Domain
  3. NM_165341.3NP_724285.1  diaphanous, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724285.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P48608
    UniProtKB/TrEMBL
    M9PDV1
    Related
    FBpp0080941, FBtr0081411
    Conserved Domains (3) summary
    pfam02181
    Location:601976
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:246446
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:59241
    Drf_GBD; Diaphanous GTPase-binding Domain
  4. NM_001259184.1NP_001246113.1  diaphanous, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246113.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9NCZ5
    Related
    FBpp0297103, FBtr0305961
    Conserved Domains (3) summary
    pfam02181
    Location:608983
    FH2; Formin Homology 2 Domain
    pfam06367
    Location:253453
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:66248
    Drf_GBD; Diaphanous GTPase-binding Domain
  5. NM_001259183.1NP_001246112.1  diaphanous, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246112.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D1Z399
    Related
    FBpp0297102, FBtr0305960
    Conserved Domains (1) summary
    pfam06371
    Location:66114
    Drf_GBD; Diaphanous GTPase-binding Domain
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