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ZNF233 zinc finger protein 233 [ Homo sapiens (human) ]

Gene ID: 353355, updated on 9-Sep-2025
Official Symbol
ZNF233provided by HGNC
Official Full Name
zinc finger protein 233provided by HGNC
Primary source
HGNC:HGNC:30946
See related
Ensembl:ENSG00000159915 AllianceGenome:HGNC:30946
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in testis (RPKM 6.0), brain (RPKM 0.9) and 6 other tissues See more
Orthologs
all
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See ZNF233 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (44259886..44275317)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (47082752..47098164)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44764039..44779470)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14757 Neighboring gene zinc finger protein 226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14758 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14759 Neighboring gene zinc finger protein 227 Neighboring gene uncharacterized LOC124904726 Neighboring gene zinc finger protein 235 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 1

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Knockdown of ZNF233 suppresses hepatocellular carcinoma cell proliferation and tumorigenesis. Xie W, et al. Gene, 2018 Dec 30. PMID 30179682
  2. Differential expansion of zinc-finger transcription factor loci in homologous human and mouse gene clusters. Shannon M, et al. Genome Res, 2003 Jun. PMID 12743021, Free PMC Article
  3. A GO catalogue of human DNA-binding transcription factors. Lovering RC, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34673265
  4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. Kahle JJ, et al. Hum Mol Genet, 2011 Feb 1. PMID 21078624, Free PMC Article
  5. NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85α to drive tumorigenesis. Zhi F, et al. Nat Commun, 2023 Sep 28. PMID 37770465, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
zinc finger protein 233
NP_001193934.1

Length

  • 670
NP_861421.2

Length

  • 670

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207005.2 → NP_001193934.1  zinc finger protein 233 isoform 1

    See identical proteins and their annotated locations for NP_001193934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK055310, BC136734, CR743367, DB071795
    Consensus CDS
    CCDS33047.1
    UniProtKB/Swiss-Prot
    A6NK53, B2RN78, B2RN79, Q86WL8
    Related
    ENSP00000507588.1, ENST00000683810.1
    Conserved Domains (4) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:450 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566 → 586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634 → 657
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001330529.2 → NP_001317458.1  zinc finger protein 233 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR and uses an alternate splice site which results in a frameshift, compared to variant 1. The enocoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC138470, AK055310, CR743367
    Consensus CDS
    CCDS82363.1
    UniProtKB/TrEMBL
    K7ER86
    Related
    ENSP00000468154.1, ENST00000592581.5

  3. NM_181756.3 → NP_861421.2  zinc finger protein 233 isoform 1

    See identical proteins and their annotated locations for NP_861421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC138470, AK095351, BC136734, CR743367, DA393180
    Consensus CDS
    CCDS33047.1
    UniProtKB/Swiss-Prot
    A6NK53, B2RN78, B2RN79, Q86WL8
    Related
    ENSP00000375820.1, ENST00000391958.6
    Conserved Domains (4) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:450 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566 → 586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634 → 657
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    44259886..44275317
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026758.3 → XP_016882247.1  zinc finger protein 233 isoform X4

  2. XM_024451488.2 → XP_024307256.1  zinc finger protein 233 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:65 → 123
    KRAB; krueppel associated box
    COG5048
    Location:507 → 656
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623 → 643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:677 → 699
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:691 → 714
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017026760.3 → XP_016882249.1  zinc finger protein 233 isoform X6

    UniProtKB/TrEMBL
    K7ER86

  4. XM_047438766.1 → XP_047294722.1  zinc finger protein 233 isoform X3

  5. XM_017026761.2 → XP_016882250.1  zinc finger protein 233 isoform X5

    UniProtKB/TrEMBL
    K7EJE5
    Related
    ENSP00000465136.1, ENST00000588489.5

  6. XM_024451489.2 → XP_024307257.1  zinc finger protein 233 isoform X2

    UniProtKB/Swiss-Prot
    A6NK53, B2RN78, B2RN79, Q86WL8
    Related
    ENSP00000617800.1, ENST00000947741.1
    Conserved Domains (4) summary
    smart00349
    Location:8 → 66
    KRAB; krueppel associated box
    COG5048
    Location:450 → 599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566 → 586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634 → 657
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    47082752..47098164
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054320867.1 → XP_054176842.1  zinc finger protein 233 isoform X6

    UniProtKB/TrEMBL
    K7ER86

  2. XM_054320861.1 → XP_054176836.1  zinc finger protein 233 isoform X8

  3. XM_054320860.1 → XP_054176835.1  zinc finger protein 233 isoform X8

  4. XM_054320865.1 → XP_054176840.1  zinc finger protein 233 isoform X9

  5. XM_054320859.1 → XP_054176834.1  zinc finger protein 233 isoform X7

  6. XM_054320864.1 → XP_054176839.1  zinc finger protein 233 isoform X4

  7. XM_054320866.1 → XP_054176841.1  zinc finger protein 233 isoform X5

    UniProtKB/TrEMBL
    K7EJE5

  8. XM_054320863.1 → XP_054176838.1  zinc finger protein 233 isoform X3

  9. XM_054320862.1 → XP_054176837.1  zinc finger protein 233 isoform X8

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NK53.3 GenPept UniProtKB/Swiss-Prot:A6NK53

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