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ZNF233 zinc finger protein 233 [ Homo sapiens (human) ]

Gene ID: 353355, updated on 2-Oct-2018

Summary

Official Symbol
ZNF233provided by HGNC
Official Full Name
zinc finger protein 233provided by HGNC
Primary source
HGNC:HGNC:30946
See related
Ensembl:ENSG00000159915 Vega:OTTHUMG00000182354
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in testis (RPKM 6.0), brain (RPKM 0.9) and 6 other tissues See more
Orthologs

Genomic context

See ZNF233 in Genome Data Viewer
Location:
19q13.31
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (44259742..44278534)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44764033..44779470)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 226 Neighboring gene zinc finger protein 227 Neighboring gene zinc finger protein 235 Neighboring gene mitochondrial ribosomal protein S15 pseudogene 2 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Pathways from BioSystems

  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001207005.1NP_001193934.1  zinc finger protein 233 isoform 1

    See identical proteins and their annotated locations for NP_001193934.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has a different 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK055310, BC136734, CR743367, DB071795
    Consensus CDS
    CCDS33047.1
    UniProtKB/Swiss-Prot
    A6NK53
    Conserved Domains (4) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:450599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634657
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001330529.1NP_001317458.1  zinc finger protein 233 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has a different 5' UTR and uses an alternate splice site which results in a frameshift, compared to variant 1. The enocoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC138470, AK055310, CR743367
    Consensus CDS
    CCDS82363.1
    UniProtKB/TrEMBL
    K7ER86
    Related
    ENSP00000468154.1, ENST00000592581.5
  3. NM_181756.2NP_861421.2  zinc finger protein 233 isoform 1

    See identical proteins and their annotated locations for NP_861421.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AK095351, BC136734, CR743367, DA393180
    Consensus CDS
    CCDS33047.1
    UniProtKB/Swiss-Prot
    A6NK53
    Related
    ENSP00000375820.1, OTTHUMP00000269050, ENST00000391958.6, OTTHUMT00000460737
    Conserved Domains (4) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:450599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634657
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    44259742..44278534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026760.2XP_016882249.1  zinc finger protein 233 isoform X4

    UniProtKB/TrEMBL
    K7ER86
  2. XM_024451488.1XP_024307256.1  zinc finger protein 233 isoform X1

    Conserved Domains (5) summary
    smart00349
    Location:65123
    KRAB; krueppel associated box
    COG5048
    Location:507656
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:623643
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:677699
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:691714
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017026758.2XP_016882247.1  zinc finger protein 233 isoform X3

  4. XM_024451489.1XP_024307257.1  zinc finger protein 233 isoform X2

    Conserved Domains (4) summary
    smart00349
    Location:866
    KRAB; krueppel associated box
    COG5048
    Location:450599
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:566586
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:634657
    zf-H2C2_2; Zinc-finger double domain
  5. XM_017026761.1XP_016882250.1  zinc finger protein 233 isoform X5

    Related
    ENSP00000465136.1, OTTHUMP00000269049, ENST00000588489.5, OTTHUMT00000460736
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