U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

DNMT3B DNA methyltransferase 3 beta [ Bos taurus (domestic cattle) ]

Gene ID: 353354, updated on 5-Sep-2025
Official Symbol
DNMT3Bprovided by VGNC
Official Full Name
DNA methyltransferase 3 betaprovided by VGNC
Primary source
VGNC:VGNC:28147
See related
BGD:BT12381; EnsemblRapid:ENSBTAG00070030307
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See DNMT3B in Genome Data Viewer
Location:
chromosome: 13
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (62142409..62176735)

Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene COMM domain containing 7 Neighboring gene uncharacterized LOC112449325 Neighboring gene microtubule associated protein RP/EB family member 1 Neighboring gene EF-hand calcium binding domain 8

Genomic Sequence:
NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Dominette sequence data
  • BioProject: PRJNA294306
  • Analysis date: Tue Dec 17 08:57:05 2024

Related articles in PubMed

  1. Dynamics of DNA methylation during early development of the preimplantation bovine embryo. Dobbs KB, et al. PLoS One, 2013. PMID 23799080, Free PMC Article
  2. The expression levels of DNMT3a/3b and their relationship with meat quality in beef cattle. Guo X, et al. Mol Biol Rep, 2012 May. PMID 22193622
  3. Analysis of DNA (cytosine 5) methyltransferase mRNA sequence and expression in bovine preimplantation embryos, fetal and adult tissues. Golding MC, et al. Gene Expr Patterns, 2003 Oct. PMID 12971987
  4. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Developmental changes in expression of DNMT3B are indicative of a possible role in changes in methylation in cattle.
    Title: Dynamics of DNA methylation during early development of the preimplantation bovine embryo.
  2. The expression levels of DNMT3a and DNMT3b were associated with several beef quality traits.
    Title: The expression levels of DNMT3a/3b and their relationship with meat quality in beef cattle.
Submit: New GeneRIF Correction

Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 
Preferred Names
DNA (cytosine-5)-methyltransferase 3B
Names
DNA (cytosine-5-)-methyltransferase 3 beta
NP_861529.2

Length

  • 844
XP_024856106.1
XP_024856107.1
XP_024856108.1
XP_024856110.1
XP_024856111.1
XP_059748397.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181813.2 → NP_861529.2  DNA (cytosine-5)-methyltransferase 3B

    Status: PROVISIONAL

    Source sequence(s)
    AY244710, CR851335
    UniProtKB/TrEMBL
    Q7YS59
    Related
    ENSBTAP00070042054.1, ENSBTAT00070068904.1
    Conserved Domains (4) summary
    cd05835
    Location:232 → 320
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    PHA03249
    Location:78 → 236
    PHA03249; DNA packaging tegument protein UL25; Provisional
    COG0270
    Location:565 → 747
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:422 → 541
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    62142409..62176735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025000338.2 → XP_024856106.1  DNA (cytosine-5)-methyltransferase 3B isoform X1

    UniProtKB/TrEMBL
    A0AAA9T499
    Conserved Domains (3) summary
    cd05835
    Location:232 → 318
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:563 → 745
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:420 → 539
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

  2. XM_025000342.2 → XP_024856110.1  DNA (cytosine-5)-methyltransferase 3B isoform X4

    UniProtKB/TrEMBL
    A0A3Q1LVT5
    Conserved Domains (3) summary
    cd05835
    Location:232 → 318
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:563 → 725
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:420 → 539
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

  3. XM_025000339.2 → XP_024856107.1  DNA (cytosine-5)-methyltransferase 3B isoform X2

    UniProtKB/TrEMBL
    A0AAA9T499
    Conserved Domains (3) summary
    cd05835
    Location:229 → 315
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:560 → 742
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:417 → 536
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

  4. XM_025000340.2 → XP_024856108.1  DNA (cytosine-5)-methyltransferase 3B isoform X3

    UniProtKB/TrEMBL
    A0AAA9T499, A0AAA9TKL9
    Related
    ENSBTAP00070042154.1, ENSBTAT00070069122.1
    Conserved Domains (3) summary
    cd05835
    Location:226 → 312
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:557 → 739
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:414 → 533
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

  5. XM_025000343.2 → XP_024856111.1  DNA (cytosine-5)-methyltransferase 3B isoform X5

    UniProtKB/TrEMBL
    A0A3Q1LVT5, A0A3Q1M6A6
    Related
    ENSBTAP00070042233.1, ENSBTAT00070069297.1
    Conserved Domains (3) summary
    cd05835
    Location:226 → 312
    Dnmt3b_related; The PWWP domain is an essential component of DNA methyltransferase 3 B (Dnmt3b) which is responsible for establishing DNA methylation patterns during embryogenesis and gametogenesis. In tumorigenesis, DNA methylation by Dnmt3b is known to play a role in ...
    COG0270
    Location:557 → 719
    Dcm; Site-specific DNA-cytosine methylase [Replication, recombination and repair]
    cd11728
    Location:414 → 533
    ADDz_Dnmt3b; ADDz domain found in DNA (cytosine-5) methyltransferases (C5-MTases) 3b (Dnmt3b)

  6. XM_059892414.1 → XP_059748397.1  DNA (cytosine-5)-methyltransferase 3B isoform X6

    UniProtKB/TrEMBL
    F1MD29, Q7YS57
    Related
    ENSBTAP00070042001.1, ENSBTAT00070068796.1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials