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Opn5 opsin 5 [ Mus musculus (house mouse) ]

Gene ID: 353344, updated on 8-Nov-2022

Summary

Official Symbol
Opn5provided by MGI
Official Full Name
opsin 5provided by MGI
Primary source
MGI:MGI:2662912
See related
Ensembl:ENSMUSG00000043972 AllianceGenome:MGI:2662912
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PGR12; Gpr136; TMEM13; Neuropsin
Summary
Enables 11-cis retinal binding activity and G protein-coupled photoreceptor activity. Involved in entrainment of circadian clock by photoperiod; hyaloid vascular plexus regression; and phototransduction, UV. Predicted to be located in cytoplasm and plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human OPN5 (opsin 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See Opn5 in Genome Data Viewer
Location:
17; 17 B3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (42867670..42922321, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (42556779..42611430, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene serine palmitoyltransferase small subunit A pseudogene Neighboring gene patched domain containing 4 Neighboring gene adhesion G protein-coupled receptor F4 Neighboring gene adhesion G protein-coupled receptor F2 Neighboring gene 40S ribosomal protein S2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis retinal binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 11-cis retinal binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 11-cis retinal binding ISO
Inferred from Sequence Orthology
more info
 
enables G protein-coupled photoreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled photoreceptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables G protein-coupled receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables photoreceptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to UV-A ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to light stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cellular response to light stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in entrainment of circadian clock by photoperiod IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hyaloid vascular plexus regression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction, UV IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phototransduction, UV ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within visual perception IEA
Inferred from Electronic Annotation
more info
 
involved_in visual perception IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
opsin-5
Names
G protein-coupled receptor 136
G-protein coupled receptor PGR12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181753.4NP_861418.2  opsin-5

    See identical proteins and their annotated locations for NP_861418.2

    Status: PROVISIONAL

    Source sequence(s)
    AC110552
    Consensus CDS
    CCDS37619.1
    UniProtKB/Swiss-Prot
    Q6VZZ7, Q8BYI2
    UniProtKB/TrEMBL
    A0A8C6G9Q1
    Related
    ENSMUSP00000063542.7, ENSMUST00000068355.8
    Conserved Domains (1) summary
    pfam00001
    Location:50306
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    42867670..42922321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006524453.1XP_006524516.1  opsin-5 isoform X1

    Conserved Domains (1) summary
    cd15074
    Location:7278
    7tmA_Opsin5_neuropsin; neuropsin (Opsin-5), member of the class A family of seven-transmembrane G protein-coupled receptors
  2. XM_017317518.1XP_017173007.1  opsin-5 isoform X2

    Conserved Domains (2) summary
    cd14964
    Location:3561
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:34140
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily