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KRTAP12-1 keratin associated protein 12-1 [ Homo sapiens (human) ]

Gene ID: 353332, updated on 15-Jun-2019

Summary

Official Symbol
KRTAP12-1provided by HGNC
Official Full Name
keratin associated protein 12-1provided by HGNC
Primary source
HGNC:HGNC:20529
See related
Ensembl:ENSG00000187175
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KAP12.1; KRTAP12.1
Orthologs

Genomic context

See KRTAP12-1 in Genome Data Viewer
Location:
21q22.3
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (44681576..44682163, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46101491..46102078, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene thrombospondin type laminin G domain and EAR repeats Neighboring gene keratin associated protein 12-2 Neighboring gene inner membrane mitochondrial protein pseudogene 1 Neighboring gene keratin associated protein 10-12 Neighboring gene keratin associated protein 10-13, pseudogene

Genomic regions, transcripts, and products

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
keratin filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin-associated protein 12-1
Names
high sulfur keratin-associated protein 12.1
keratin-associated protein 12.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181686.2NP_859014.1  keratin-associated protein 12-1

    See identical proteins and their annotated locations for NP_859014.1

    Status: VALIDATED

    Source sequence(s)
    AJ566388
    Consensus CDS
    CCDS42966.1
    UniProtKB/Swiss-Prot
    P59990
    Related
    ENSP00000375475.1, ENST00000391617.1
    Conserved Domains (1) summary
    pfam13885
    Location:1053
    Keratin_B2_2; Keratin, high sulfur B2 protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44681576..44682163 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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