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Tbx3 T-box 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353305, updated on 2-Oct-2018

Summary

Official Symbol
Tbx3provided by RGD
Official Full Name
T-box 3provided by RGD
Primary source
RGD:735203
See related
Ensembl:ENSRNOG00000008706
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
human homolog acts as a transcriptional repressor and plays a role in the development of several organ systems [RGD, Feb 2006]
Expression
Biased expression in Adrenal (RPKM 379.4), Lung (RPKM 114.2) and 5 other tissues See more
Orthologs

Genomic context

See Tbx3 in Genome Data Viewer
Location:
12q16
Exon count:
10
Annotation release Status Assembly Chr Location
106 current Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (42479518..42494588, complement)
104 previous assembly Rnor_5.0 (GCF_000001895.4) 12 NC_005111.3 (44326928..44342670, complement)

Chromosome 12 - NC_005111.4Genomic Context describing neighboring genes Neighboring gene 2'-5' oligoadenylate synthetase 1G Neighboring gene 2'-5'-oligoadenylate synthase 1A-like Neighboring gene uncharacterized LOC102551526 Neighboring gene uncharacterized LOC108352453

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
animal organ morphogenesis ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior axis specification, embryo ISO
Inferred from Sequence Orthology
more info
 
anterior/posterior axis specification, embryo ISS
Inferred from Sequence or Structural Similarity
more info
 
atrioventricular bundle cell differentiation IEA
Inferred from Electronic Annotation
more info
 
atrioventricular bundle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
blood vessel development IEA
Inferred from Electronic Annotation
more info
 
blood vessel development ISO
Inferred from Sequence Orthology
more info
 
branching involved in mammary gland duct morphogenesis IEA
Inferred from Electronic Annotation
more info
 
branching involved in mammary gland duct morphogenesis ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell differentiation ISO
Inferred from Sequence Orthology
more info
 
cardiac muscle cell fate commitment IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell fate commitment ISO
Inferred from Sequence Orthology
more info
 
cell aging ISO
Inferred from Sequence Orthology
more info
 
cell aging ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular senescence ISO
Inferred from Sequence Orthology
more info
 
cellular senescence ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic digit morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic digit morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
embryonic forelimb morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
embryonic heart tube development ISO
Inferred from Sequence Orthology
more info
 
embryonic hindlimb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
embryonic hindlimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
female genitalia development ISO
Inferred from Sequence Orthology
more info
 
female genitalia development ISS
Inferred from Sequence or Structural Similarity
more info
 
follicle-stimulating hormone secretion ISO
Inferred from Sequence Orthology
more info
 
follicle-stimulating hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
forelimb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
heart looping IEA
Inferred from Electronic Annotation
more info
 
heart looping ISO
Inferred from Sequence Orthology
more info
 
heart morphogenesis ISO
Inferred from Sequence Orthology
more info
 
in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
in utero embryonic development ISO
Inferred from Sequence Orthology
more info
 
limb morphogenesis ISO
Inferred from Sequence Orthology
more info
 
limbic system development IEA
Inferred from Electronic Annotation
more info
 
limbic system development ISO
Inferred from Sequence Orthology
more info
 
luteinizing hormone secretion ISO
Inferred from Sequence Orthology
more info
 
luteinizing hormone secretion ISS
Inferred from Sequence or Structural Similarity
more info
 
male genitalia development ISO
Inferred from Sequence Orthology
more info
 
male genitalia development ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary gland development ISO
Inferred from Sequence Orthology
more info
 
mammary gland development ISS
Inferred from Sequence or Structural Similarity
more info
 
mammary placode formation IEA
Inferred from Electronic Annotation
more info
 
mammary placode formation ISO
Inferred from Sequence Orthology
more info
 
mesoderm morphogenesis ISO
Inferred from Sequence Orthology
more info
 
mesoderm morphogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
negative regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of epithelial cell differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation ISO
Inferred from Sequence Orthology
more info
 
negative regulation of myoblast differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
 
outflow tract morphogenesis IEA
Inferred from Electronic Annotation
more info
 
outflow tract morphogenesis ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of stem cell proliferation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
regulation of cell proliferation ISO
Inferred from Sequence Orthology
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development IEA
Inferred from Electronic Annotation
more info
 
roof of mouth development ISO
Inferred from Sequence Orthology
more info
 
sinoatrial node cell development IEA
Inferred from Electronic Annotation
more info
 
sinoatrial node cell development ISO
Inferred from Sequence Orthology
more info
 
skeletal system development ISO
Inferred from Sequence Orthology
more info
 
skeletal system development ISS
Inferred from Sequence or Structural Similarity
more info
 
specification of animal organ position IEA
Inferred from Electronic Annotation
more info
 
specification of animal organ position ISO
Inferred from Sequence Orthology
more info
 
stem cell population maintenance IEA
Inferred from Electronic Annotation
more info
 
stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
 
ventricular septum morphogenesis IEA
Inferred from Electronic Annotation
more info
 
ventricular septum morphogenesis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
nucleus ISO
Inferred from Sequence Orthology
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
transcription factor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
T-box transcription factor TBX3
Names
T-box 3 (ulnar mammary syndrome)
T-box protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181638.1NP_853669.1  T-box transcription factor TBX3

    Status: PROVISIONAL

    Source sequence(s)
    AY289619
    UniProtKB/Swiss-Prot
    Q7TST9
    Related
    ENSRNOP00000011552.2, ENSRNOT00000011552.4
    Conserved Domains (2) summary
    pfam12598
    Location:323413
    TBX; T-box transcription factor
    cd00182
    Location:102307
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Rnor_6.0 Primary Assembly

Genomic

  1. NC_005111.4 Reference Rnor_6.0 Primary Assembly

    Range
    42479518..42494588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006249416.3XP_006249478.1  T-box transcription factor TBX3 isoform X1

    UniProtKB/Swiss-Prot
    Q7TST9
    Conserved Domains (2) summary
    pfam12598
    Location:323413
    TBX; T-box transcription factor
    cd00182
    Location:102307
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  2. XM_006249417.3XP_006249479.1  T-box transcription factor TBX3 isoform X1

    UniProtKB/Swiss-Prot
    Q7TST9
    Conserved Domains (2) summary
    pfam12598
    Location:323413
    TBX; T-box transcription factor
    cd00182
    Location:102307
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  3. XM_006249415.2XP_006249477.1  T-box transcription factor TBX3 isoform X1

    UniProtKB/Swiss-Prot
    Q7TST9
    Conserved Domains (2) summary
    pfam12598
    Location:323413
    TBX; T-box transcription factor
    cd00182
    Location:102307
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...
  4. XM_006249418.1XP_006249480.1  T-box transcription factor TBX3 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K8D7
    Related
    ENSRNOP00000074567.1, ENSRNOT00000084018.1
    Conserved Domains (2) summary
    pfam12598
    Location:303393
    TBX; T-box transcription factor
    cd00182
    Location:102287
    TBOX; T-box DNA binding domain of the T-box family of transcriptional regulators. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA ...

Alternate Rn_Celera

Genomic

  1. AC_000080.1 Alternate Rn_Celera

    Range
    38555497..38566664 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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