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IKKepsilon I-kappaB kinase epsilon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35329, updated on 28-Aug-2019

Summary

Official Symbol
IKKepsilonprovided by FlyBase
Official Full Name
I-kappaB kinase epsilonprovided by FlyBase
Primary source
FLYBASE:FBgn0086657
Locus tag
Dmel_CG2615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
38D.31; APTX7; CG2615; dik2; Dik2; DIK2; dIKK; dIKKepsilon; Dmel\CG2615; Dmik2; DmIKKepsilon; DmIKKepsilon/dIK2; ik2; Ik2; IK2; Ik2/DmIKK; IKK; ikkepsilon; l(2)38Ea

Genomic context

See IKKepsilon in Genome Data Viewer
Location:
38D4-38D5; 2-54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (20676045..20678979)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (20676045..20678979)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45004 Neighboring gene Centrocortin Neighboring gene uncharacterized protein Neighboring gene Hormone receptor-like in 38 Neighboring gene long non-coding RNA:CR44187

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
Rab GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
actin filament bundle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell death IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
endocytic recycling IMP
Inferred from Mutant Phenotype
more info
PubMed 
maintenance of epithelial integrity, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
microtubule bundle formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuron remodeling IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte anterior/posterior axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein trans-autophosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cytoskeleton organization IPI
Inferred from Physical Interaction
more info
PubMed 
sensory organ precursor cell division IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
cell tip IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
I-kappaB kinase epsilon
Names
CG2615-PB
CG2615-PC
IKK-related kinase
IKKepsilon-PB
IKKepsilon-PC
IkappaB kinase-like 2
apoptoxin 7
ik2
lethal (2) 38Ea
NP_610048.2
NP_724278.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    20676045..20678979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_136204.3NP_610048.2  I-kappaB kinase epsilon, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_610048.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3Y8
    Related
    FBpp0307790, FBtr0336824
    Conserved Domains (3) summary
    cd12219
    Location:299389
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:18332
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1
    pfam00069
    Location:16297
    Pkinase; Protein kinase domain
  2. NM_165337.2NP_724278.1  I-kappaB kinase epsilon, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724278.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V3Y8
    Related
    FBpp0080920, FBtr0081390
    Conserved Domains (3) summary
    cd12219
    Location:299389
    UBL_TBK1_like; Ubiquitin-Like Domain Of Human Tbk1 and similar proteins
    cd13988
    Location:18332
    STKc_TBK1; Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1
    pfam00069
    Location:16297
    Pkinase; Protein kinase domain
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