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KRT26 keratin 26 [ Homo sapiens (human) ]

Gene ID: 353288, updated on 18-Aug-2020

Summary

Official Symbol
KRT26provided by HGNC
Official Full Name
keratin 26provided by HGNC
Primary source
HGNC:HGNC:30840
See related
Ensembl:ENSG00000186393 MIM:616675
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K25; K26; CK26; KRT25B; K25IRS2
Summary
The protein encoded by this gene is a member of the keratin superfamily. This keratin protein is a type I keratin that is specific for the inner root sheath of the hair follicle. This gene exists in a cluster with other keratin genes on chromosome 17q21. [provided by RefSeq, Jul 2009]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See KRT26 in Genome Data Viewer
Location:
17q21.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40766238..40772159, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (38922490..38928411, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 223, pseudogene Neighboring gene keratin 25 Neighboring gene keratin 27 Neighboring gene keratin 28

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 26
Names
CK-26
K25B
cytokeratin-26
keratin 26, type I
keratin-25B
type I inner root sheath specific keratin 25 irs2
type I inner root sheath-specific keratin-K25irs2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012487.1 RefSeqGene

    Range
    5001..10922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_181539.4NP_853517.2  keratin, type I cytoskeletal 26

    See identical proteins and their annotated locations for NP_853517.2

    Status: REVIEWED

    Source sequence(s)
    AJ564205, BC132951
    Consensus CDS
    CCDS11374.1
    UniProtKB/Swiss-Prot
    Q7Z3Y9
    Related
    ENSP00000334798.4, ENST00000335552.4
    Conserved Domains (2) summary
    pfam00038
    Location:82395
    Filament; Intermediate filament protein
    pfam16208
    Location:173
    Keratin_2_head; Keratin type II head

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40766238..40772159 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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