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ZNF445 zinc finger protein 445 [ Homo sapiens (human) ]

Gene ID: 353274, updated on 21-Dec-2019

Summary

Official Symbol
ZNF445provided by HGNC
Official Full Name
zinc finger protein 445provided by HGNC
Primary source
HGNC:HGNC:21018
See related
Ensembl:ENSG00000185219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP445; ZNF168; ZSCAN47; ZKSCAN15
Expression
Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF445 in Genome Data Viewer
Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (44431705..44477670, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44481262..44519162, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377055 Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene chromosome 3 open reading frame 86 Neighboring gene long intergenic non-protein coding RNA 1988 Neighboring gene uncharacterized LOC101928529 Neighboring gene zinc finger protein 852

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126535

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
zinc finger protein 445
Names
zinc finger protein 168
zinc finger protein with KRAB and SCAN domains 15

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369454.1NP_001356383.1  zinc finger protein 445 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873
    Conserved Domains (4) summary
    smart00431
    Location:51155
    SCAN; leucine rich region
    smart00349
    Location:222280
    KRAB; krueppel associated box
    COG5048
    Location:5831019
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:475495
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_181489.6NP_852466.1  zinc finger protein 445 isoform 1

    See identical proteins and their annotated locations for NP_852466.1

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873, BX108541
    Consensus CDS
    CCDS2713.1
    UniProtKB/Swiss-Prot
    P59923
    Related
    ENSP00000379387.2, ENST00000396077.8
    Conserved Domains (8) summary
    smart00431
    Location:51155
    SCAN; leucine rich region
    smart00349
    Location:234292
    KRAB; krueppel associated box
    COG5048
    Location:5951031
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:487507
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:485507
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:234273
    KRAB; KRAB box
    pfam02023
    Location:51139
    SCAN; SCAN domain
    pfam13465
    Location:777799
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    44431705..44477670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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