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ZNF445 zinc finger protein 445 [ Homo sapiens (human) ]

Gene ID: 353274, updated on 6-Sep-2022

Summary

Official Symbol
ZNF445provided by HGNC
Official Full Name
zinc finger protein 445provided by HGNC
Primary source
HGNC:HGNC:21018
See related
Ensembl:ENSG00000185219 MIM:619508; AllianceGenome:HGNC:21018
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZFP445; ZNF168; ZSCAN47; ZKSCAN15
Summary
Enables double-stranded methylated DNA binding activity. Involved in maintenance of DNA methylation and regulation of genetic imprinting. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 3.6), brain (RPKM 3.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF445 in Genome Data Viewer
Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (44431705..44477670, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (44447545..44493482, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (44473197..44519162, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene T cell activation inhibitor, mitochondrial Neighboring gene long intergenic non-protein coding RNA 694 Neighboring gene long intergenic non-protein coding RNA 1988 Neighboring gene uncharacterized LOC101928529 Neighboring gene zinc finger protein 852

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC126535

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded methylated DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 445
Names
zinc finger protein 168
zinc finger protein with KRAB and SCAN domains 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001369454.1NP_001356383.1  zinc finger protein 445 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873
    UniProtKB/TrEMBL
    B7ZKX2
    Conserved Domains (4) summary
    smart00431
    Location:51155
    SCAN; leucine rich region
    smart00349
    Location:222280
    KRAB; krueppel associated box
    COG5048
    Location:5831019
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:475495
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_181489.6NP_852466.1  zinc finger protein 445 isoform 1

    See identical proteins and their annotated locations for NP_852466.1

    Status: VALIDATED

    Source sequence(s)
    AC134943, AY295873, BX108541
    Consensus CDS
    CCDS2713.1
    UniProtKB/Swiss-Prot
    P59923, Q3MJD1
    Related
    ENSP00000379387.2, ENST00000396077.8
    Conserved Domains (4) summary
    smart00431
    Location:51155
    SCAN; leucine rich region
    smart00349
    Location:234292
    KRAB; krueppel associated box
    COG5048
    Location:5951031
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:487507
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    44431705..44477670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    44447545..44493482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)