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RAMACL RNA guanine-7 methyltransferase activating subunit like [ Homo sapiens (human) ]

Gene ID: 353267, updated on 18-Sep-2024

Summary

Official Symbol
RAMACLprovided by HGNC
Official Full Name
RNA guanine-7 methyltransferase activating subunit likeprovided by HGNC
Primary source
HGNC:HGNC:21234
See related
Ensembl:ENSG00000235272 AllianceGenome:HGNC:21234
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAMMETL; C6orf119; RAMMETP1; FAM103A2P; dJ427A4.2
Summary
Predicted to enable RNA binding activity. Predicted to be involved in methylation and recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex. Predicted to be part of mRNA cap binding activity complex and mRNA cap methyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

See RAMACL in Genome Data Viewer
Location:
6q27
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (166583009..166586678, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (167961081..167964751, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (166996497..167000166, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S6 kinase A2 Neighboring gene RPS6KA2 intronic transcript 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883915-166884818 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166883011-166883914 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166889542-166890188 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166899351-166899851 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166903150-166903650 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166908262-166908949 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:166917274-166918473 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166920565-166921504 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166919624-166920564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166946507-166947008 Neighboring gene microRNA 1913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25435 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25436 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:166955818-166956418 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166956766-166957686 Neighboring gene NANOG hESC enhancer GRCh37_chr6:166965189-166965763 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166978541-166979078 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:166985773-166986662 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993250-166993750 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:166993751-166994251 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:166994332-166995152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17778 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25437 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25438 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167032008-167032774 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr6:167034435-167034935 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17780 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17781 Neighboring gene uncharacterized LOC107986671 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167068910-167069464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:167103273-167103941 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:167107051-167108250 Neighboring gene insulin like growth factor 2 mRNA binding protein 3 pseudogene

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC2560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in RNA 5'-cap (guanine-N7)-methylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of mRNA capping enzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
RNA guanine-N7 methyltransferase-activating subunit-like protein
Names
RNA guanine-7 methyltransferase activating subunit like (pseudogene)
RNMT activating mRNA cap methyltransferase subunit like (pseudogene)
RNMT activating mRNA cap methyltransferase subunit pseudogene 1
family with sequence similarity 103 member A2, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395999.1NP_001382928.1  RNA guanine-N7 methyltransferase-activating subunit-like protein

    Status: VALIDATED

    Source sequence(s)
    Z98049
    Consensus CDS
    CCDS94031.1
    UniProtKB/Swiss-Prot
    A0A3B3IU46
    Related
    ENSP00000498060.1, ENST00000444122.3
    Conserved Domains (1) summary
    pfam15320
    Location:1087
    RAM; mRNA cap methylation, RNMT-activating mini protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    166583009..166586678 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    167961081..167964751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001012240.1: Suppressed sequence

    Description
    NM_001012240.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.