tnnt2c troponin T2c, cardiac [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tnnt2cprovided by ZNC
Official Full Name: troponin T2c, cardiacprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030520-1
See related: Ensembl:ENSDARG00000032242 AllianceGenome:ZFIN:ZDB-GENE-030520-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: stnt; cb328; sb:cb328; zgc:86847
Summary: Predicted to enable tropomyosin binding activity; troponin C binding activity; and troponin I binding activity. Acts upstream of or within sarcomere organization. Predicted to be part of troponin complex. Is expressed in mesoderm; musculature system; somite; and trunk mesenchyme. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple). Orthologous to human TNNT2 (troponin T2, cardiac type). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	4	NC_007115.7 (12031973..12033866)
105	previous assembly	GRCz10 (GCF_000002035.5)	4	NC_007115.6 (12033124..12035017)

Chromosome 4 - NC_007115.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Complete loss of troponin T3a, T3b and T2c activities leads to loss of sarcomere structure.
Title: Troponin T is essential for sarcomere assembly in zebrafish skeletal muscle.
Tnnt1, Tnnt2, and Tnnt3b were conserved in the central tropomyosin- and C-terminal troponin I-binding domains but the N-terminal hypervariable regions were highly extended and rich in glutamic acid in polypeptides of Tnnt1 and Tnnt2, but not Tnnt3b.
Title: Molecular structure and developmental expression of three muscle-type troponin T genes in zebrafish.

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General gene information

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Markers

fc48g01 (e-PCR)
- UniSTS:189234

fc64b01.y1 (e-PCR)
- UniSTS:194184

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables tropomyosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin C binding	IBA Inferred from Biological aspect of Ancestor more info
enables troponin I binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cardiac muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of muscle contraction	IEA Inferred from Electronic Annotation more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sarcomere organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: troponin T2c, cardiac

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.