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Prune2 prune homolog 2 [ Mus musculus (house mouse) ]

Gene ID: 353211, updated on 2-Jul-2024

Summary

Official Symbol
Prune2provided by MGI
Official Full Name
prune homolog 2provided by MGI
Primary source
MGI:MGI:1925004
See related
Ensembl:ENSMUSG00000039126 AllianceGenome:MGI:1925004
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bmcc1; Olfaxin; mKIAA0367; 6330414G02Rik; A230083H22Rik; A330102H22Rik
Summary
Predicted to enable pyrophosphatase activity. Predicted to be involved in apoptotic process. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; limb; nervous system; sensory organ; and urinary system. Orthologous to human PRUNE2 (prune homolog 2 with BCH domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 10.0), frontal lobe adult (RPKM 5.5) and 10 other tissues See more
Orthologs
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Genomic context

See Prune2 in Genome Data Viewer
Location:
19 B; 19 12.34 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (16933033..17201322)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (16955668..17223963)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene forkhead box B2 Neighboring gene predicted gene, 32341 Neighboring gene STARR-seq mESC enhancer starr_45670 Neighboring gene STARR-seq mESC enhancer starr_45671 Neighboring gene STARR-seq mESC enhancer starr_45673 Neighboring gene STARR-seq mESC enhancer starr_45676 Neighboring gene STARR-positive B cell enhancer ABC_E4271 Neighboring gene STARR-seq mESC enhancer starr_45678 Neighboring gene STARR-seq mESC enhancer starr_45679 Neighboring gene glucosaminyl (N-acetyl) transferase 1, core 2 Neighboring gene STARR-seq mESC enhancer starr_45680 Neighboring gene STARR-positive B cell enhancer ABC_E3246 Neighboring gene riboflavin kinase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA0367

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables pyrophosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
protein prune homolog 2
Names
BNIP2 motif-containing molecule at the C-terminal region 1
neuronal protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181348.4NP_851993.3  protein prune homolog 2

    See identical proteins and their annotated locations for NP_851993.3

    Status: VALIDATED

    Source sequence(s)
    AC126674, AC147026, AK039241, BC094224
    Consensus CDS
    CCDS50400.1
    UniProtKB/Swiss-Prot
    Q501M3, Q52KR3, Q6A079, Q8BW65, Q8BYM6, Q9D217
    Related
    ENSMUSP00000084977.5, ENSMUST00000087689.5
    Conserved Domains (4) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam02833
    Location:220313
    DHHA2; DHHA2 domain
    pfam12496
    Location:27822899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29013022
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    16933033..17201322
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527145.3XP_006527208.1  protein prune homolog 2 isoform X2

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822891
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29033040
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  2. XM_006527149.4XP_006527212.1  protein prune homolog 2 isoform X10

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  3. XM_006527147.4XP_006527210.1  protein prune homolog 2 isoform X5

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  4. XM_006527152.4XP_006527215.1  protein prune homolog 2 isoform X14

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  5. XM_006527151.4XP_006527214.1  protein prune homolog 2 isoform X13

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  6. XM_036161615.1XP_036017508.1  protein prune homolog 2 isoform X11

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  7. XM_006527153.4XP_006527216.1  protein prune homolog 2 isoform X16

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  8. XM_017318226.3XP_017173715.1  protein prune homolog 2 isoform X3

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822898
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29003037
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  9. XM_017318229.3XP_017173718.1  protein prune homolog 2 isoform X9

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822898
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29003037
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  10. XM_036161614.1XP_036017507.1  protein prune homolog 2 isoform X6

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  11. XM_036161616.1XP_036017509.1  protein prune homolog 2 isoform X12

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043035
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  12. XM_006527144.4XP_006527207.1  protein prune homolog 2 isoform X1

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  13. XM_006527146.3XP_006527209.1  protein prune homolog 2 isoform X4

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822892
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29043041
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  14. XM_017318228.3XP_017173717.1  protein prune homolog 2 isoform X8

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29013038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  15. XM_017318230.3XP_017173719.1  protein prune homolog 2 isoform X15

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29013038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  16. XM_017318227.3XP_017173716.1  protein prune homolog 2 isoform X7

    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29013038
    CRAL_TRIO_2; Divergent CRAL/TRIO domain
  17. XM_006527154.4XP_006527217.1  protein prune homolog 2 isoform X17

    UniProtKB/Swiss-Prot
    Q52KR3
    Conserved Domains (3) summary
    COG1227
    Location:24284
    PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
    pfam12496
    Location:27822899
    BNIP2; Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2
    pfam13716
    Location:29013032
    CRAL_TRIO_2; Divergent CRAL/TRIO domain

RNA

  1. XR_004940154.1 RNA Sequence