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Nr1d2 nuclear receptor subfamily 1, group D, member 2 [ Mus musculus (house mouse) ]

Gene ID: 353187, updated on 11-Apr-2024

Summary

Official Symbol
Nr1d2provided by MGI
Official Full Name
nuclear receptor subfamily 1, group D, member 2provided by MGI
Primary source
MGI:MGI:2449205
See related
Ensembl:ENSMUSG00000021775 AllianceGenome:MGI:2449205
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RVR; Rev-erb
Summary
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. [provided by RefSeq, Feb 2014]
Expression
Broad expression in bladder adult (RPKM 22.5), cerebellum adult (RPKM 19.3) and 25 other tissues See more
Orthologs
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Genomic context

See Nr1d2 in Genome Data Viewer
Location:
14 A1; 14 7.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (4230549..4265639)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (18204056..18239106, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15 Neighboring gene STARR-seq mESC enhancer starr_36048 Neighboring gene predicted gene 7084 Neighboring gene STARR-seq mESC enhancer starr_36047 Neighboring gene predicted gene, 44469 Neighboring gene STARR-positive B cell enhancer mm9_chr14:18999596-18999897 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in circadian behavior IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in energy homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hormone-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of lipid metabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of skeletal muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within rhythmic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear receptor subfamily 1 group D member 2
Names
Rev-erb beta
orphan nuclear receptor RVR
rev-erb-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425894.1NP_001412823.1  nuclear receptor subfamily 1 group D member 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CU024892
  2. NM_001425895.1NP_001412824.1  nuclear receptor subfamily 1 group D member 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CU024892
  3. NM_001425896.1NP_001412825.1  nuclear receptor subfamily 1 group D member 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CU024892
  4. NM_001425897.1NP_001412826.1  nuclear receptor subfamily 1 group D member 2 isoform 5

    Status: VALIDATED

    Source sequence(s)
    CU024892
  5. NM_001425898.1NP_001412827.1  nuclear receptor subfamily 1 group D member 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    CU024892
  6. NM_001425900.1NP_001412829.1  nuclear receptor subfamily 1 group D member 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CU024892
  7. NM_001425901.1NP_001412830.1  nuclear receptor subfamily 1 group D member 2 isoform 7

    Status: VALIDATED

    Source sequence(s)
    CU024892
  8. NM_001425902.1NP_001412831.1  nuclear receptor subfamily 1 group D member 2 isoform 8

    Status: VALIDATED

    Source sequence(s)
    CU024892
  9. NM_001425903.1NP_001412832.1  nuclear receptor subfamily 1 group D member 2 isoform 9

    Status: VALIDATED

    Source sequence(s)
    CU024892
  10. NM_001425904.1NP_001412833.1  nuclear receptor subfamily 1 group D member 2 isoform 10

    Status: VALIDATED

    Source sequence(s)
    CU024892
  11. NM_011584.5NP_035714.3  nuclear receptor subfamily 1 group D member 2 isoform 1

    See identical proteins and their annotated locations for NP_035714.3

    Status: VALIDATED

    Source sequence(s)
    CU024892
    Consensus CDS
    CCDS36811.1
    UniProtKB/Swiss-Prot
    Q60646, Q60674
    UniProtKB/TrEMBL
    Q4VAB7, Q8C598
    Related
    ENSMUSP00000088031.6, ENSMUST00000090543.6
    Conserved Domains (2) summary
    cd06940
    Location:386574
    NR_LBD_REV_ERB; The ligand binding domain of REV-ERB receptors, members of the nuclear receptor superfamily
    cd07166
    Location:98186
    NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    4230549..4265639
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158687.1XP_036014580.1  nuclear receptor subfamily 1 group D member 2 isoform X1

    UniProtKB/TrEMBL
    Q8C598
    Conserved Domains (2) summary
    cd07166
    Location:98186
    NR_DBD_REV_ERB; DNA-binding domain of REV-ERB receptor-like is composed of two C4-type zinc fingers
    cl11397
    Location:386512
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

RNA

  1. XR_004938413.1 RNA Sequence

  2. XR_004938414.1 RNA Sequence