U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mc1r melanocortin 1 receptor [ Danio rerio (zebrafish) ]

Gene ID: 353151, updated on 9-Sep-2025
Official Symbol
mc1rprovided by ZNC
Official Full Name
melanocortin 1 receptorprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030502-1
See related
Ensembl:ENSDARG00000020237 AllianceGenome:ZFIN:ZDB-GENE-030502-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary
Predicted to enable melanocyte-stimulating hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Located in plasma membrane. Is expressed in several structures, including endocrine system; female organism; integument; male organism; and nervous system. Human ortholog(s) of this gene implicated in familial melanoma; major depressive disorder; melanoma; oculocutaneous albinism type II; and pigmentation disease. Orthologous to human MC1R (melanocortin 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table
See mc1r in Genome Data Viewer
Location:
chromosome: 18
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 18 NC_133193.1 (32819525..32822432, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 18 NC_007129.7 (31224914..31227719, complement)

Chromosome 18 - NC_133193.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC141378851 Neighboring gene programmed cell death 5 Neighboring gene TCF25 ribosome quality control complex subunit Neighboring gene differentially expressed in FDCP 8 homolog Neighboring gene uncharacterized LOC141378848 Neighboring gene uncharacterized LOC141378850

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. In Vitro, In Vivo, and In Silico Analyses of Molecular Anti-Pigmentation Mechanisms of Selected Thai Rejuvenating Remedy and Bioactive Metabolites. Dej-Adisai S, et al. Molecules, 2023 Jan 18. PMID 36770624, Free PMC Article
  2. mc1r Pathway regulation of zebrafish melanosome dispersion. Richardson J, et al. Zebrafish, 2008 Dec. PMID 19133827
  3. Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish. Cal L, et al. Pigment Cell Melanoma Res, 2019 Nov. PMID 31251842
  4. Melanocortin receptor accessory protein 2 (MRAP2) interplays with the zebrafish melanocortin 1 receptor (MC1R) but has no effect on its pharmacological profile. Cortés R, et al. Gen Comp Endocrinol, 2014 May 15. PMID 24709359
  5. Pulsed Electromagnetic Fields Increase Pigmentation through the p-ERK/p-p38 Pathway in Zebrafish (Danio rerio). Kim YM, et al. Int J Mol Sci, 2018 Oct 17. PMID 30336610, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. loss-of-function of mc1r causes a reduction of countershading and a general paling of the animals.
    Title: Loss-of-function mutations in the melanocortin 1 receptor cause disruption of dorso-ventral countershading in teleost fish.
  2. This study demonstrated a direct role for mc1r in zebrafish melanosome dispersal in response to background, and used chemical modification of this pathway to uncover a possible new layer of regulation in melanosome dispersal in zebrafish.
    Title: mc1r Pathway regulation of zebrafish melanosome dispersion.
  3. Evolution of mc1r in zebrafish is reported.
    Title: Evolution of melanocortin receptors in teleost fish: the melanocortin type 1 receptor.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables melanocortin receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables melanocyte-stimulating hormone receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables melanocyte-stimulating hormone receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in melanin biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cAMP/PKA signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
melanocyte-stimulating hormone receptor
Names
melanocortin 1 receptor protein

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_180970.1 → NP_851301.1  melanocyte-stimulating hormone receptor

    See identical proteins and their annotated locations for NP_851301.1

    Status: PROVISIONAL

    Source sequence(s)
    AY161847
    UniProtKB/TrEMBL
    B3DHP2, Q7ZTA3
    Related
    ENSDARP00000008075.6, ENSDART00000003210.8
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 300
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:50 → 186
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133193.1 Reference GRCz12tu Primary Assembly

    Range
    32819525..32822432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159179.6 → XP_005159236.1  melanocyte-stimulating hormone receptor isoform X1

    See identical proteins and their annotated locations for XP_005159236.1

    UniProtKB/TrEMBL
    B3DHP2, Q7ZTA3
    Conserved Domains (2) summary
    pfam00001
    Location:60 → 300
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:50 → 186
    7tm_4; Olfactory receptor
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous