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TBC1D26 TBC1 domain family member 26 [ Homo sapiens (human) ]

Gene ID: 353149, updated on 4-Nov-2022

Summary

Official Symbol
TBC1D26provided by HGNC
Official Full Name
TBC1 domain family member 26provided by HGNC
Primary source
HGNC:HGNC:28745
See related
Ensembl:ENSG00000214946 AllianceGenome:HGNC:28745
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 8.9) See more
Orthologs
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Genomic context

See TBC1D26 in Genome Data Viewer
Location:
17p12
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (15732277..15744784)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (15638589..15651097)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (15635591..15648098)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene tripartite motif containing 16 Neighboring gene zinc finger protein 29, pseudogene Neighboring gene ZNF286A-TBC1D26 readthrough (NMD candidate) Neighboring gene zinc finger protein 286A Neighboring gene ubiquitin conjugating enzyme E2 S pseudogene 1 Neighboring gene TBC1D26 antisense RNA 1 Neighboring gene uncharacterized LOC105371559 Neighboring gene CDRT15 pseudogene 2 Neighboring gene zinc finger SWIM-type containing 5 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ55788, FLJ78711, MGC51025

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TBC1 domain family member 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001388465.1NP_001375394.1  TBC1 domain family member 26 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC005324
    Consensus CDS
    CCDS92260.1
    UniProtKB/TrEMBL
    A0A8J8ZQP4
    Related
    ENSP00000410111.3, ENST00000437605.4
    Conserved Domains (1) summary
    smart00164
    Location:98306
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
  2. NM_178571.4NP_848666.2  TBC1 domain family member 26 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC005324, AI631546, BC047400, DB067071, EG328144
    Consensus CDS
    CCDS42265.1
    UniProtKB/Swiss-Prot
    Q86UD7
    Related
    ENSP00000434391.1, ENST00000469477.3
    Conserved Domains (1) summary
    smart00164
    Location:98225
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    15732277..15744784
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    15638589..15651097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)