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LCE3E late cornified envelope 3E [ Homo sapiens (human) ]

Gene ID: 353145, updated on 5-Aug-2022

Summary

Official Symbol
LCE3Eprovided by HGNC
Official Full Name
late cornified envelope 3Eprovided by HGNC
Primary source
HGNC:HGNC:29463
See related
Ensembl:ENSG00000185966 MIM:612617; AllianceGenome:HGNC:29463
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEP17
Summary
Predicted to be involved in keratinization. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in esophagus (RPKM 2.4) and skin (RPKM 2.3) See more
Orthologs
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Genomic context

See LCE3E in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152565654..152566780, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151702207..151703333, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152538130..152539256, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 5A Neighboring gene cysteine rich C-terminal 1 Neighboring gene late cornified envelope 3D Neighboring gene late cornified envelope 3C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
EBI GWAS Catalog
Web-based, participant-driven studies yield novel genetic associations for common traits.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
late cornified envelope protein 3E
Names
late envelope protein 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178435.4NP_848522.1  late cornified envelope protein 3E

    See identical proteins and their annotated locations for NP_848522.1

    Status: VALIDATED

    Source sequence(s)
    AL356426, BC131716
    Consensus CDS
    CCDS1013.1
    UniProtKB/Swiss-Prot
    A2RRM6, Q5T5B0
    Related
    ENSP00000357778.1, ENST00000368789.2
    Conserved Domains (1) summary
    pfam14672
    Location:2555
    LCE; Late cornified envelope

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152565654..152566780 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151702207..151703333 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)