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LCE3C late cornified envelope 3C [ Homo sapiens (human) ]

Gene ID: 353144, updated on 13-May-2022

Summary

Official Symbol
LCE3Cprovided by HGNC
Official Full Name
late cornified envelope 3Cprovided by HGNC
Primary source
HGNC:HGNC:16612
See related
Ensembl:ENSG00000244057 MIM:612615; AllianceGenome:HGNC:16612
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEP15; SPRL3A
Summary
Involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and killing of cells of other organism. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See LCE3C in Genome Data Viewer
Location:
1q21.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (152600234..152601086)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (151736788..151737640)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152572710..152573562)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 3E Neighboring gene late cornified envelope 3D Neighboring gene late cornified envelope 3B Neighboring gene late cornified envelope 3A

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of late cornified envelope 3C (LCE3C) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
late cornified envelope protein 3C
Names
late envelope protein 15
small proline rich-like (epidermal differentiation complex) 3A
small proline-rich-like epidermal differentiation complex protein 3A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178434.3NP_848521.1  late cornified envelope protein 3C

    See identical proteins and their annotated locations for NP_848521.1

    Status: VALIDATED

    Source sequence(s)
    AL356426
    Consensus CDS
    CCDS1015.1
    UniProtKB/Swiss-Prot
    Q5T5A8
    Related
    ENSP00000507204.1, ENST00000684028.1
    Conserved Domains (1) summary
    pfam14672
    Location:2594
    LCE; Late cornified envelope

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    152600234..152601086
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    151736788..151737640
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)