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LCE1A late cornified envelope 1A [ Homo sapiens (human) ]

Gene ID: 353131, updated on 23-Nov-2021

Summary

Official Symbol
LCE1Aprovided by HGNC
Official Full Name
late cornified envelope 1Aprovided by HGNC
Primary source
HGNC:HGNC:29459
See related
Ensembl:ENSG00000186844 MIM:612603
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LEP1
Summary
LCE1A belongs to the late cornified envelope (LCE) gene cluster within the epidermal differentiation complex (EDC) on chromosome 1. The LCE cluster contains multiple conserved genes that encode stratum corneum proteins, and these genes are expressed relatively late during fetal assembly of the skin cornified envelope (Jackson et al., 2005 [PubMed 15854049]). For further information on the LCE gene cluster, see GENE FAMILY below.[supplied by OMIM, Feb 2009]
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Genomic context

See LCE1A in Genome Data Viewer
Location:
1q21.3
Exon count:
1
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (152827473..152828097)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (152799949..152800573)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene late cornified envelope 1C Neighboring gene late cornified envelope 1B Neighboring gene late cornified envelope 6A Neighboring gene uncharacterized LOC122526777

Genomic regions, transcripts, and products

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in keratinization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
late cornified envelope protein 1A
Names
late envelope protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178348.2NP_848125.1  late cornified envelope protein 1A

    See identical proteins and their annotated locations for NP_848125.1

    Status: VALIDATED

    Source sequence(s)
    AL162596
    Consensus CDS
    CCDS1028.1
    UniProtKB/Swiss-Prot
    Q5T7P2
    Related
    ENSP00000334869.2, ENST00000335123.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    152827473..152828097
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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