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MAST1 microtubule associated serine/threonine kinase 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 353118, updated on 30-Sep-2021

Summary

Official Symbol
MAST1provided by RGD
Official Full Name
microtubule associated serine/threonine kinase 1provided by RGD
Primary source
RGD:631372
See related
EnsemblRapid:ENSRNOG00000003469
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sast
Summary
interacts with syntrophin on the cell surface [RGD, Feb 2006]
Expression
Restricted expression toward (RPKM 41.8) See more
Orthologs
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Genomic context

See MAST1 in Genome Data Viewer
Location:
19q11
Exon count:
26
Annotation release Status Assembly Chr Location
108 current mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (23216418..23244224)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (26026045..26053762, complement)

Chromosome 19 - NC_051354.1Genomic Context describing neighboring genes Neighboring gene ribonuclease H2, subunit A Neighboring gene thrombospondin type 1 domain containing 8 Neighboring gene retbindin Neighboring gene microRNA 3550 Neighboring gene deoxyribonuclease 2, lysosomal Neighboring gene Kruppel like factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables magnesium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein serine/threonine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in brain development ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in dendrite IEA
Inferred from Electronic Annotation
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
microtubule-associated serine/threonine-protein kinase 1
Names
syntrophin associated serine/threonine kinase
syntrophin-associated serine/threonine-protein kinase
NP_851603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181089.2NP_851603.1  microtubule-associated serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_851603.1

    Status: VALIDATED

    Source sequence(s)
    JACYVU010000313
    UniProtKB/Swiss-Prot
    Q810W7
    Related
    ENSRNOP00000004646.2, ENSRNOT00000004646.4
    Conserved Domains (4) summary
    smart00220
    Location:376649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd00992
    Location:9701052
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd05609
    Location:375654
    STKc_MAST; Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase
    pfam08926
    Location:61337
    DUF1908; Domain of unknown function (DUF1908)

RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mRatBN7.2 Primary Assembly

Genomic

  1. NC_051354.1 Reference mRatBN7.2 Primary Assembly

    Range
    23216418..23244224
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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