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RAET1G retinoic acid early transcript 1G [ Homo sapiens (human) ]

Gene ID: 353091, updated on 25-Jan-2022

Summary

Official Symbol
RAET1Gprovided by HGNC
Official Full Name
retinoic acid early transcript 1Gprovided by HGNC
Primary source
HGNC:HGNC:16795
See related
Ensembl:ENSG00000203722 MIM:609244; AllianceGenome:HGNC:16795
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ULBP5
Summary
This gene encodes a member of the major histocompatibility complex (MHC) class I family of proteins. Although the encoded protein includes C-terminal transmembrane and cytoplasmic domains, proteolytic processing results in the removal of these domains and subsequent tethering to the plasma membrane by a glycosylphosphatidylinositol (GPI)-anchor. The encoded protein is one of several related ligands of the natural killer group 2, member D (NKG2D) receptor, which functions as an activating receptor in innate and adaptive immunity. This gene is present in a gene cluster on chromosome 6. [provided by RefSeq, Jul 2015]
Expression
Biased expression in esophagus (RPKM 1.3), adrenal (RPKM 0.9) and 11 other tissues See more
Orthologs
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Genomic context

See RAET1G in Genome Data Viewer
Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (149916878..149923133, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (150238014..150244257, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RAET1E antisense RNA 1 Neighboring gene multimerin 2 pseudogene Neighboring gene retinoic acid early transcript 1F pseudogene Neighboring gene uncharacterized LOC105378052 Neighboring gene UL16 binding protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Nef nef HIV-1 (SF2) Nef downregulates RAET1G (ULBP5); downregulation is dependent upon residues G2 and F195 and a di-lysine motif in Nef as shown in A3.01 T cells and HeLa TZM-bl cells PubMed
Vpu vpu HIV-1 (NL4-3) Vpu downregulates RAET1G (ULBP5); downregulation is dependent upon amino acids R30/K31, V25/Y29, the acidic di-leucine motif in Vpu helix 2 as shown in A3.01 T cells and HeLa TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables natural killer cell lectin-like receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in anchored component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
UL-16 binding protein 5
Names
retinoic acid early transcript 1G protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001788.4NP_001001788.2  UL-16 binding protein 5 preproprotein

    See identical proteins and their annotated locations for NP_001001788.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, also known as RAET1G1) represents the longer transcript and encodes the protein.
    Source sequence(s)
    AY172579, AY172580, HY165961
    Consensus CDS
    CCDS43514.1
    UniProtKB/Swiss-Prot
    Q6H3X3
    Related
    ENSP00000356329.2, ENST00000367360.7
    Conserved Domains (1) summary
    cl08246
    Location:29198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2

RNA

  1. NR_130110.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, also known as RAET1G2) uses an alternate splice site at an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AY172580, HY165961
    Related
    ENST00000367361.6

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    149916878..149923133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535800.3XP_011534102.1  UL-16 binding protein 5 isoform X2

    Conserved Domains (1) summary
    cl08246
    Location:29198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
  2. XM_017010831.2XP_016866320.1  UL-16 binding protein 5 isoform X1

    Conserved Domains (1) summary
    cl08246
    Location:29198
    MHC_I; Class I Histocompatibility antigen, domains alpha 1 and 2
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