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tph1a tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) a [ Danio rerio (zebrafish) ]

Gene ID: 352943, updated on 14-Jun-2025
Official Symbol
tph1aprovided by ZNC
Official Full Name
tryptophan hydroxylase 1 (tryptophan 5-monooxygenase) aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030317-1
See related
Ensembl:ENSDARG00000029432 AllianceGenome:ZFIN:ZDB-GENE-030317-1
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
tph; tph1; tphD1; tph1-1
Summary
Predicted to enable tryptophan 5-monooxygenase activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation and response to hypoxia. Predicted to be active in neuron projection. Is expressed in nervous system; neural tube; and ovary. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and heroin dependence. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Jun 2025]
Orthologs
human mouse all
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See tph1a in Genome Data Viewer
Location:
chromosome: 25
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2025_04 current GRCz12tu (GCF_049306965.1) 25 NC_133200.1 (8846440..8867277, complement)
RS_2024_08 previous assembly GRCz11 (GCF_000002035.6) 25 NC_007136.7 (8138917..8160012, complement)

Chromosome 25 - NC_133200.1Genomic Context describing neighboring genes Neighboring gene dehydrogenase E1 and transketolase domain containing 1 Neighboring gene potassium voltage-gated channel, Shaw-related subfamily, member 1b Neighboring gene secretion regulating guanine nucleotide exchange factor Neighboring gene uncharacterized LOC141380887 Neighboring gene uncharacterized LOC141380888 Neighboring gene serum amyloid A-like 1 Neighboring gene mucin 5d

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Related articles in PubMed

  1. Nucleotide distance influences co-methylation between nearby CpG sites. Affinito O, et al. Genomics, 2020 Jan. PMID 31078719
  2. Cloning of two tryptophan hydroxylase genes expressed in the diencephalon of the developing zebrafish brain. Bellipanni G, et al. Mech Dev, 2002 Dec. PMID 14516688
  3. Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates). Xavier AL, et al. J Comp Neurol, 2017 Jun 15. PMID 28295297, Free PMC Article
  4. DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish. Cuomo M, et al. Biomolecules, 2021 Jan 22. PMID 33499115, Free PMC Article
  5. The serotonergic phenotype is acquired by converging genetic mechanisms within the zebrafish central nervous system. Lillesaar C, et al. Dev Dyn, 2007 Apr. PMID 17304529

See all (75) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio).
    Title: Disruption of tph1 genes demonstrates the importance of serotonin in regulating ventilation in larval zebrafish (Danio rerio).
  2. DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.
    Title: DNA Methylation Profiles of Tph1A and BDNF in Gut and Brain of L. Rhamnosus-Treated Zebrafish.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 5-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within response to hypoxia IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin biosynthetic process from tryptophan IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
Preferred Names
tryptophan 5-hydroxylase 1a
Names
tryptophan hydroxylase (tryptophan 5-monooxygenase
NP_840091.2
XP_017209547.2
XP_073797929.1

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178306.3 → NP_840091.2  tryptophan 5-hydroxylase 1a

    See identical proteins and their annotated locations for NP_840091.2

    Status: PROVISIONAL

    Source sequence(s)
    BC059550
    UniProtKB/TrEMBL
    A0A8M1PC40, Q6PBX4
    Related
    ENSDARP00000067158.4, ENSDART00000067159.6
    Conserved Domains (3) summary
    TIGR01270
    Location:50 → 478
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:57 → 130
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:145 → 475
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

RefSeqs of Annotated Genomes: GCF_049306965.1-RS_2025_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz12tu Primary Assembly

Genomic

  1. NC_133200.1 Reference GRCz12tu Primary Assembly

    Range
    8846440..8867277 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017354058.4 → XP_017209547.2  tryptophan 5-hydroxylase 1a isoform X1

  2. XM_073941828.1 → XP_073797929.1  tryptophan 5-hydroxylase 1a isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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