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fgfr2 fibroblast growth factor receptor 2 [ Danio rerio (zebrafish) ]

Gene ID: 352940, updated on 8-Aug-2021

Summary

Official Symbol
fgfr2provided by ZNC
Official Full Name
fibroblast growth factor receptor 2provided by ZNC
Primary source
ZFIN:ZDB-GENE-030323-1
See related
Ensembl:ENSDARG00000058115
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
fgfr-2; fgfr2b; fgfr2c; fc56c05; wu:fc56c05
Orthologs
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Genomic context

See fgfr2 in Genome Data Viewer
Location:
chromosome: 13
Exon count:
19
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (46298560..46429450, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (46162095..46293000, complement)
103 previous assembly Zv9 (GCF_000002035.4) 13 NC_007124.5 (46909744..47040645, complement)

Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene finTRIM family, member 70 Neighboring gene finTRIM family, member 69 Neighboring gene arginyltransferase 1 Neighboring gene transmembrane protein 63Ba

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables fibroblast growth factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables fibroblast growth factor-activated receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables fibroblast growth factor-activated receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell proliferation in midbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of heart left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of liver left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within determination of pancreatic left/right asymmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of hematopoietic stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
fibroblast growth factor receptor 2
NP_001229933.1
NP_001229934.1
NP_001229935.1
NP_840088.2
XP_005169609.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243004.1NP_001229933.1  fibroblast growth factor receptor 2 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    CU639430, CU862017, FP102866
    Related
    ENSDARP00000124761.1, ENSDART00000149125.3
    Conserved Domains (7) summary
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:271360
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00409
    Location:174248
    IG; Immunoglobulin
    smart00410
    Location:263359
    IG_like; Immunoglobulin like
    cd05101
    Location:452764
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:477753
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:48125
    Ig; Immunoglobulin domain
  2. NM_001243005.1NP_001229934.1  fibroblast growth factor receptor 2 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks one coding exon and includes another, compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    CU639430, CU862017, FP102866
    UniProtKB/TrEMBL
    F1RBT3
    Related
    ENSDARP00000123845.1, ENSDART00000149602.2
    Conserved Domains (5) summary
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:263357
    IG_like; Immunoglobulin like
    cd05101
    Location:450762
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:475751
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:271358
    Ig; Immunoglobulin domain
  3. NM_001243006.1NP_001229935.1  fibroblast growth factor receptor 2 isoform 4 precursor

    See identical proteins and their annotated locations for NP_001229935.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks a coding exon compared to variant 1. The resulting protein (isoform 4) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    CU639430, CU862017, FP102866
    UniProtKB/TrEMBL
    A4QN31
    Related
    ENSDARP00000089041.4, ENSDART00000098269.6
    Conserved Domains (5) summary
    cd05857
    Location:75159
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:182271
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00410
    Location:174270
    IG_like; Immunoglobulin like
    cd05101
    Location:363675
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:388664
    Pkinase_Tyr; Protein tyrosine kinase
  4. NM_178303.3NP_840088.2  fibroblast growth factor receptor 2 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternative splice site in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
    Source sequence(s)
    CU639430, CU862017, FP102866
    UniProtKB/TrEMBL
    F1RBS5
    Related
    ENSDARP00000124472.1, ENSDART00000150061.3
    Conserved Domains (7) summary
    cd05857
    Location:164248
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    cd05858
    Location:271360
    Ig3_FGFR-2; Third immunoglobulin (Ig)-like domain of fibroblast growth factor receptor 2 (FGFR2)
    smart00409
    Location:174248
    IG; Immunoglobulin
    smart00410
    Location:263359
    IG_like; Immunoglobulin like
    cd05101
    Location:450762
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:475751
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:48125
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007124.7 Reference GRCz11 Primary Assembly

    Range
    46298560..46429450 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005169552.4XP_005169609.1  fibroblast growth factor receptor 2 isoform X1

    Conserved Domains (5) summary
    cd05857
    Location:187271
    Ig2_FGFR; Second immunoglobulin (Ig)-like domain of fibroblast growth factor (FGF) receptor
    smart00410
    Location:286380
    IG_like; Immunoglobulin like
    cd05101
    Location:471783
    PTKc_FGFR2; Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2
    pfam07714
    Location:496772
    Pkinase_Tyr; Protein tyrosine kinase
    cl11960
    Location:294381
    Ig; Immunoglobulin domain
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