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selenop selenoprotein P [ Danio rerio (zebrafish) ]

Gene ID: 352931, updated on 27-Mar-2024

Summary

Official Symbol
selenopprovided by ZNC
Official Full Name
selenoprotein Pprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030311-1
See related
Ensembl:ENSDARG00000093549 AllianceGenome:ZFIN:ZDB-GENE-030311-1
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
SePPa; SelPa; cb688; sepp1a; wu:fa55a04; wu:fb38a09; wu:fj79f04
Summary
This gene encodes a selenoprotein that is predominantly expressed in the liver and secreted into the plasma in mammals. This selenoprotein is unique in that it contains multiple selenocysteine (Sec) residues per polypeptide (17 in zebrafish), and accounts for most of the selenium in plasma. It has been implicated as an extracellular antioxidant, and in the transport of selenium to extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2). Mice lacking this gene exhibit neurological dysfunction, suggesting its importance in normal brain function. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs in vertebrates contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The mRNA for this selenoprotein contains two SECIS elements. A paralog of this gene exists on chromosome 2 (GeneID:791479). [provided by RefSeq, Aug 2017]
Orthologs
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Genomic context

See selenop in Genome Data Viewer
Location:
chromosome: 8
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 8 NC_007119.7 (31435586..31443262)
105 previous assembly GRCz10 (GCF_000002035.5) 8 NC_007119.6 (31426351..31434014)

Chromosome 8 - NC_007119.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101887121 Neighboring gene uncharacterized LOC101887043 Neighboring gene zinc finger protein 131 Neighboring gene uncharacterized LOC103911520 Neighboring gene growth hormone receptor a Neighboring gene transfer RNA valine (anticodon AAC) Neighboring gene F-box protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables selenium binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables selenium binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in selenium compound metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within selenium compound metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenoprotein Pa
Names
selenoprotein P, 1a
selenoprotein P, plasma, 1a
zSelPa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178297.4NP_840082.3  selenoprotein Pa precursor

    Status: REVIEWED

    Source sequence(s)
    AL929453, AL935153
    UniProtKB/Swiss-Prot
    Q98SV1
    UniProtKB/TrEMBL
    A0A8M1PAF5
    Related
    ENSDARP00000116562.1, ENSDART00000145282.2
    Conserved Domains (2) summary
    pfam04593
    Location:272351
    SelP_C; Selenoprotein P, C terminal region
    pfam04592
    Location:23201
    SelP_N; Selenoprotein P, N terminal region

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007119.7 Reference GRCz11 Primary Assembly

    Range
    31435586..31443262
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394733.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    192350..197565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)