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msrb1a methionine sulfoxide reductase B1a [ Danio rerio (zebrafish) ]

Gene ID: 352916, updated on 27-Mar-2024

Summary

Official Symbol
msrb1aprovided by ZNC
Official Full Name
methionine sulfoxide reductase B1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030411-3
See related
Ensembl:ENSDARG00000025436 AllianceGenome:ZFIN:ZDB-GENE-030411-3
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
MsrB; SePR; selx; cb687; sepx1; SelX-A; sepx1a; MsrB1-A; wu:fa03e09
Summary
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A paralog of this gene (msrb1b) exists on chromosome 12. [provided by RefSeq, Oct 2016]
Orthologs
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Genomic context

See msrb1a in Genome Data Viewer
Location:
chromosome: 3
Exon count:
4
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (18798431..18805297, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (18649165..18655540, complement)

Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene hydroxyacylglutathione hydrolase Neighboring gene fumarylacetoacetate hydrolase domain containing 1 Neighboring gene transportin 2a Neighboring gene transmembrane protein 104

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide-methionine (R)-S-oxide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide-methionine (R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within innate immune response IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein repair IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methionine-R-sulfoxide reductase B1-A
Names
methionine-R-sulfoxide reductase B1
msrB1
selenoprotein X, 1
selenoprotein X, 1a
selenoprotein X-A
NP_840073.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178288.5NP_840073.2  methionine-R-sulfoxide reductase B1-A

    See identical proteins and their annotated locations for NP_840073.2

    Status: REVIEWED

    Source sequence(s)
    AL772362, EH525837, EH536771, EH572189
    UniProtKB/Swiss-Prot
    Q6NWX6, Q802G6
    Related
    ENSDARP00000122736.1, ENSDART00000131758.3
    Conserved Domains (1) summary
    cl15841
    Location:6110
    SelR; SelR domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007114.7 Reference GRCz11 Primary Assembly

    Range
    18798431..18805297 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)