selenow1 selenoprotein W, 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: selenow1provided by ZNC
Official Full Name: selenoprotein W, 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030410-5
See related: Ensembl:ENSDARG00000035136 AllianceGenome:ZFIN:ZDB-GENE-030410-5
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: selW; cb694; sepw1; fe37b06; selenow; wu:fe37b06; wu:fk70h03; zgc:109781
Summary: This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Unlike in mammals, where this protein is highly expressed in skeletal muscle, heart and brain; it is expressed in sensory organs in zebrafish. Paralogs of this gene, sepw2a and sepw2b, are found on chromosome 3. [provided by RefSeq, Jul 2017]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2025_04	current	GRCz12tu (GCF_049306965.1)	5	NC_133180.1 (67909281..67915840)
RS_2024_08	previous assembly	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (61998603..62005162)

Chromosome 5 - NC_133180.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fe37b06.x1 (e-PCR)
- UniSTS:196416

fk70h03.x1 (e-PCR)
- UniSTS:201449

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables antioxidant activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in response to selenium ion	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: selenoprotein W; selenoprotein W, 1

Names: selenoprotein W1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.