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selenow1 selenoprotein W, 1 [ Danio rerio (zebrafish) ]

Gene ID: 352915, updated on 27-Mar-2024

Summary

Official Symbol
selenow1provided by ZNC
Official Full Name
selenoprotein W, 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-030410-5
See related
Ensembl:ENSDARG00000035136 AllianceGenome:ZFIN:ZDB-GENE-030410-5
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
selW; cb694; sepw1; fe37b06; selenow; wu:fe37b06; wu:fk70h03; zgc:109781
Summary
This gene encodes a selenoprotein containing a selenocysteine (Sec) residue, which is encoded by the UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein belongs to the SelWTH family, which possesses a thioredoxin-like fold and a conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox function for this gene. Unlike in mammals, where this protein is highly expressed in skeletal muscle, heart and brain; it is expressed in sensory organs in zebrafish. Paralogs of this gene, sepw2a and sepw2b, are found on chromosome 3. [provided by RefSeq, Jul 2017]
Orthologs
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Genomic context

See selenow1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
6
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (61998603..62005162)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (61335866..61342425)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene si:dkeyp-117b8.4 Neighboring gene zinc finger protein 541 Neighboring gene EH-domain containing 2a Neighboring gene A kinase (PRKA) anchor protein 10 Neighboring gene transmembrane protein 211 Neighboring gene spermatogenesis associated 22

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables antioxidant activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in response to selenium ion IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
selenoprotein W; selenoprotein W, 1
Names
selenoprotein W1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_178287.5NP_840072.3  selenoprotein W, 1

    See identical proteins and their annotated locations for NP_840072.3

    Status: REVIEWED

    Source sequence(s)
    EH445855, EH564833, EH593497
    UniProtKB/Swiss-Prot
    Q568W0
    UniProtKB/TrEMBL
    Q802G9
    Related
    ENSDARP00000117583.2, ENSDART00000137110.2
    Conserved Domains (1) summary
    TIGR02174
    Location:577
    CXXU_selWTH; selT/selW/selH selenoprotein domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    61998603..62005162
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)