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swm second mitotic wave missing [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35235, updated on 18-Sep-2024

Summary

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Official Symbol
swmprovided by FlyBase
Official Full Name
second mitotic wave missingprovided by FlyBase
Primary source
FLYBASE:FBgn0002044
Locus tag
Dmel_CG10084
See related
AllianceGenome:FB:FBgn0002044
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10084; Dmel\CG10084; E1; EC2-10; l(2)37Dh; l(2)E1; S(rux)2B; S(Rux)2B; Swm; Swm1
Summary
Enables mRNA binding activity. Involved in negative regulation of mRNA polyadenylation; positive regulation of RNA export from nucleus; and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including embryonic/larval digestive system; embryonic/larval fat body; embryonic/larval garland cell; embryonic/larval optic lobe; and ventral midline of embryo. Orthologous to human RBM26 (RNA binding motif protein 26) and RBM27 (RNA binding motif protein 27). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See swm in Genome Data Viewer
Location:
37E4-37E4; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19493251..19497978)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19493251..19497978)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cytosolic thiouridylase subunit 2 Neighboring gene Topoisomerase 3alpha Neighboring gene cysts

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Drosophila melanogaster topoisomerase IIIalpha preferentially relaxes a positively or negatively supercoiled bubble substrate and is essential during development. Plank JL, et al. J Biol Chem, 2005 Feb 4. PMID 15537633
  2. Control of G1 in the developing Drosophila eye: rca1 regulates Cyclin A. Dong X, et al. Genes Dev, 1997 Jan 1. PMID 9000053
  3. Identification of genes required for neural-specific glycosylation using functional genomics. Yamamoto-Hino M, et al. PLoS Genet, 2010 Dec 23. PMID 21203496, Free PMC Article
  4. A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts. Casso DJ, et al. Genetics, 2008 Mar. PMID 18245841, Free PMC Article
  5. dLKR/SDH regulates hormone-mediated histone arginine methylation and transcription of cell death genes. Cakouros D, et al. J Cell Biol, 2008 Aug 11. PMID 18695041, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. swm is recessive lethal and is predicted to encode an evolutionarily conserved protein with RNA binding and Zn(+) finger domains.
    Title: A screen for modifiers of hedgehog signaling in Drosophila melanogaster identifies swm and mts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of RNA export from nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
second mitotic wave missing
Names
CG10084-PA
CG10084-PB
CG10084-PC
CG10084-PD
lethal (2) 37Dh
swm-PA
swm-PB
swm-PC
swm-PD

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19493251..19497978
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273657.1 → NP_001260586.1  second mitotic wave missing, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260586.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDF2
    Conserved Domains (2) summary
    cd12257
    Location:561 → 634
    RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12258
    Location:921 → 992
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

  2. NM_136132.5 → NP_609976.1  second mitotic wave missing, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609976.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B1NLF3, B1NLF4, Q9VIV2
    Related
    FBpp0080785
    Conserved Domains (2) summary
    cd12257
    Location:560 → 633
    RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12258
    Location:920 → 991
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

  3. NM_165304.2 → NP_724201.1  second mitotic wave missing, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724201.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B1NLF3, B1NLF4, Q9VIV2
    Related
    FBpp0080786
    Conserved Domains (2) summary
    cd12257
    Location:560 → 633
    RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12258
    Location:920 → 991
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins

  4. NM_001273658.1 → NP_001260587.1  second mitotic wave missing, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260587.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PDF2
    Conserved Domains (2) summary
    cd12257
    Location:561 → 634
    RRM1_RBM26_like; RNA recognition motif 1 in vertebrate RNA-binding protein 26 (RBM26) and similar proteins
    cd12258
    Location:921 → 992
    RRM2_RBM26_like; RNA recognition motif 2 of vertebrate RNA-binding protein 26 (RBM26) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PDF2 M9PDF2
Q9VIV2.1 Q9VIV2

Gene LinkOut

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