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Top2 Topoisomerase 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35225, updated on 5-Sep-2021

Summary

Official Symbol
Top2provided by FlyBase
Official Full Name
Topoisomerase 2provided by FlyBase
Primary source
FLYBASE:FBgn0284220
Locus tag
Dmel_CG10223
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10223; CHRAC; dCHRAC; Dmel\CG10223; dmTopoII; dTopoII; suo; top2; TOP2; TopII; topo 2; topo II; Topo II; TOPO II; topoII; TopoII; TOPOII
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Genomic context

See Top2 in Genome Data Viewer
Location:
37E1-37E1; 2-54 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19447365..19453490, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19447365..19453490, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ran GTPase activating protein Neighboring gene Heparan sulfate 2-O-sulfotransferase Neighboring gene uncharacterized protein Neighboring gene traffic jam

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables four-way junction DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables rDNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables satellite DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
NOT part_of ACF complex IDA
Inferred from Direct Assay
more info
PubMed 
NOT part_of CHRAC IDA
Inferred from Direct Assay
more info
PubMed 
part_of CHRAC IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with condensed chromosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
topoisomerase 2
Names
CG10223-PA
CG10223-PB
DNA topoisomerase II
DNA topoisomeriase II
Top 2
Top2-PA
Top2-PB
Topoisomerase2
solofuso
topoisomerase II
type II DNA topoisomerase
type II topoisomerase
NP_001260580.1
NP_476760.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19447365..19453490 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273651.1NP_001260580.1  topoisomerase 2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260580.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15348
    Related
    FBpp0304598, FBtr0332320
    Conserved Domains (6) summary
    cd03365
    Location:435555
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    cd00187
    Location:6911172
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:246398
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:51378
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:61155
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam16898
    Location:553691
    TOPRIM_C; C-terminal associated domain of TOPRIM
  2. NM_057412.5NP_476760.1  topoisomerase 2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476760.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P15348
    Related
    FBpp0080825, FBtr0081287
    Conserved Domains (6) summary
    cd03365
    Location:435555
    TOPRIM_TopoIIA; TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of ...
    cd00187
    Location:6911172
    TOP4c; DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA ...
    cd03481
    Location:246398
    TopoIIA_Trans_ScTopoIIA; TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded ...
    PTZ00108
    Location:51378
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam02518
    Location:61155
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
    pfam16898
    Location:553691
    TOPRIM_C; C-terminal associated domain of TOPRIM
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