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AsnRS Asparaginyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35194, updated on 8-Apr-2024

Summary

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Official Symbol
AsnRSprovided by FlyBase
Official Full Name
Asparaginyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0086443
Locus tag
Dmel_CG10687
See related
AllianceGenome:FB:FBgn0086443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aats-asn; BcDNA:GH06451; Ca; CG10687; Dmel\CG10687; l(2)37Ca; l(2)37Ca)E11; l(2)E11; NRS; SN2-8
Summary
Predicted to enable asparagine-tRNA ligase activity. Predicted to be involved in asparaginyl-tRNA aminoacylation. Predicted to be active in cytoplasm. Is expressed in adult head; embryonic/larval salivary gland; organism; and spermatozoon. Orthologous to human NARS1 (asparaginyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
37C1-37C1; 2-54 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (19129469..19131954, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (19129469..19131954, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene lethal (2) 37Cb Neighboring gene lethal (2) 37Cd Neighboring gene Dynactin 6, p27 subunit Neighboring gene RNA polymerase I and III subunit D Neighboring gene brain tumor Neighboring gene long non-coding RNA:CR44977

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental control of transduced dopa decarboxylase genes in D. melanogaster. Marsh JL, et al. Mol Gen Genet, 1985. PMID 2989656
  2. Molecular mapping of a gene cluster flanking the Drosophila Dopa decarboxylase gene. Gilbert D, et al. Genetics, 1984 Apr. PMID 6425116, Free PMC Article
  3. A diphenol oxidase gene is part of a cluster of genes involved in catecholamine metabolism and sclerotization in Drosophila. II. Molecular localization of the Dox-A2 coding region. Pentz ES, et al. Genetics, 1986 Apr. PMID 3007281, Free PMC Article
  4. The genetics of dopa decarboxylase in Drosophila melanogaster. IV. The genetics and cytology of the 37B10-37D1 region. Wright TR, et al. Chromosoma, 1981. PMID 6790250
  5. The Wilhelmine E. Key 1992 Invitational lecture. Phenotypic analysis of the Dopa decarboxylase gene cluster mutants in Drosophila melanogaster. Wright TR. J Hered, 1996 May-Jun. PMID 8683095

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables asparagine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables asparagine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asparaginyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in asparaginyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in asparaginyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Asparaginyl-tRNA synthetase
Names
AsnRS-PA
AsnRS-PB
CG10687-PA
CG10687-PB
asparaginyl-tRNA synthetase
lethal (2) 37Ca
suppressor of NA9 2-8
NP_001260561.1
NP_609948.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    19129469..19131954 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001273632.1 → NP_001260561.1  Asparaginyl-tRNA synthetase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001260561.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V434
    Conserved Domains (3) summary
    COG0017
    Location:122 → 558
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00776
    Location:233 → 552
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04323
    Location:137 → 219
    AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...

  2. NM_136104.4 → NP_609948.1  Asparaginyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_609948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V434
    Related
    FBpp0080705
    Conserved Domains (3) summary
    COG0017
    Location:122 → 558
    AsnS; Aspartyl/asparaginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]
    cd00776
    Location:233 → 552
    AsxRS_core; Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as ...
    cd04323
    Location:137 → 219
    AsnRS_cyto_like_N; AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V434 Q9V434

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