Format

Send to:

Choose Destination

IGKC immunoglobulin kappa constant [ Homo sapiens (human) ]

Gene ID: 3514, updated on 1-Jun-2020

Summary

Official Symbol
IGKCprovided by HGNC
Official Full Name
immunoglobulin kappa constantprovided by HGNC
Primary source
HGNC:HGNC:5716
See related
Ensembl:ENSG00000211592 IMGT/GENE-DB:IGKC; MIM:147200
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Km; HCAK1; IGKCD
Annotation information
Annotation category: partial on reference assembly

Genomic context

See IGKC in Genome Data Viewer
Location:
2p11.2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (88857361..88857683, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (89156874..89157196, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374854 Neighboring gene MIR4436A-IGK intergenic CAGE-defined B cell enhancer Neighboring gene immunoglobulin kappa deleting element or like Neighboring gene immunoglobulin kappa joining 5 Neighboring gene immunoglobulin kappa joining 4 Neighboring gene immunoglobulin kappa locus

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • immunoglobulin kappa (invariant region)
  • immunoglobulin kappa constant region
  • immunoglobulin kappa light chain (VJ)

Clone Names

  • MGC62011, MGC72072, MGC88770, MGC88771, MGC88809, MGC111575

Gene Ontology Provided by GOA

Function Evidence Code Pubs
antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antigen binding NAS
Non-traceable Author Statement
more info
PubMed 
immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Fc-epsilon receptor signaling pathway TAS
Traceable Author Statement
more info
 
Fc-gamma receptor signaling pathway involved in phagocytosis TAS
Traceable Author Statement
more info
 
complement activation TAS
Traceable Author Statement
more info
 
complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
complement activation, classical pathway TAS
Traceable Author Statement
more info
 
defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immune response NAS
Non-traceable Author Statement
more info
PubMed 
immunoglobulin production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
receptor-mediated endocytosis TAS
Traceable Author Statement
more info
 
regulation of complement activation TAS
Traceable Author Statement
more info
 
regulation of immune response TAS
Traceable Author Statement
more info
 
retina homeostasis HEP PubMed 
Component Evidence Code Pubs
blood microparticle HDA PubMed 
external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
extracellular region NAS
Non-traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
immunoglobulin complex IEA
Inferred from Electronic Annotation
more info
 
immunoglobulin complex, circulating IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_000834.1 

    Range
    484017..484339
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    88857361..88857683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center