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tos tosca [ Drosophila melanogaster (fruit fly) ]

Gene ID: 35119, updated on 8-Feb-2025

Summary

Official Symbol
tosprovided by FlyBase
Official Full Name
toscaprovided by FlyBase
Primary source
FLYBASE:FBgn0015553
Locus tag
Dmel_CG10387
See related
AllianceGenome:FB:FBgn0015553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10387; Dmel\CG10387; DmTosca; Tosca
Summary
Predicted to enable 5'-flap endonuclease activity; double-stranded DNA 5'-3' DNA exonuclease activity; and single-stranded DNA 5'-3' DNA exonuclease activity. Predicted to be involved in DNA recombination and mismatch repair. Predicted to be active in nucleus. Is expressed in border follicle cell; germarium region 2a; germarium region 2b; germarium region 3; and oocyte. Orthologous to human EXO1 (exonuclease 1). [provided by Alliance of Genome Resources, Feb 2025]
Orthologs
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Genomic context

See tos in Genome Data Viewer
Location:
36F11-36F11; 2-53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (18679631..18682075, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (18679631..18682075, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Male-specific transcript 36Fb Neighboring gene Male-specific transcript 36Fa Neighboring gene uncharacterized protein Neighboring gene male-specific lethal 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables 5'-3' DNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 5'-3' DNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 
enables 5'-3' exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables 5'-flap endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables double-stranded DNA 5'-3' DNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables flap endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA 5'-3' DNA exonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in DNA recombination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in DNA recombination ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in mismatch repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
tosca
Names
CG10387-PA
tos-PA
NP_477145.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    18679631..18682075 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057797.4NP_477145.1  tosca [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9EQW7, Q24557, Q24558, Q960X5
    Related
    FBpp0080675
    Conserved Domains (2) summary
    cd09908
    Location:214291
    H3TH_EXO1; H3TH domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease
    cd09857
    Location:1204
    PIN_EXO1; PIN domain of Exonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs