kon kon-tiki [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: konprovided by FlyBase
Official Full Name: kon-tikiprovided by FlyBase
Primary source: FLYBASE:FBgn0032683
Locus tag: Dmel_CG10275
See related: AllianceGenome:FB:FBgn0032683
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG10275; CT28869; Dmel\CG10275; Kon; perd
Summary: Involved in muscle attachment; positive regulation of filopodium assembly; and sarcomere organization. Located in cell tip; muscle tendon junction; and myofibril. Is expressed in several structures, including dorsal vessel primordium; embryonic/larval glial cell; embryonic/larval muscle system; extended germ band embryo; and precursor of adult central brain neuropil glia. Human ortholog(s) of this gene implicated in relapsing-remitting multiple sclerosis. Orthologous to human CSPG4 (chondroitin sulfate proteoglycan 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 36F5-36F6; 2-53 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (18487747..18503978, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (18487747..18503978, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the conserved transmembrane Drosophila proteoglycan Kon-tiki (Kon, also known as Perdido) interacts with the alphaPS2betaPS integrin (alphaPS2 is encoded by inflated and betaPS by myospheroid) to mediate muscle-tendon adhesion.
Title: Kon-tiki enhances PS2 integrin adhesion and localizes its ligand, Thrombospondin, in the myotendinous junction.
Two negative feedback loops with Notch and Pros allow Kon to drive the homeostatic regulation required for central nervous system repair.
Title: Molecular mechanism of central nervous system repair by the Drosophila NG2 homologue kon-tiki.
propose that Perd regulates projection of myotube processes the myotendinous junction by priming formation of a protein complex through its intracellular interaction with Grip and the tendon cell-expressed laminin-binding alpha PS1-beta PS integrin
Title: The transmembrane protein Perdido interacts with Grip and integrins to mediate myotube projection and attachment in the Drosophila embryo.
Kon promotes directed myotube migration and transduces a target-derived signal that initiates the formation of a stable connection.
Title: The transmembrane protein Kon-tiki couples to Dgrip to mediate myotube targeting in Drosophila.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in muscle attachment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle organ development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of filopodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sarcomere organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
located_in cell tip	IDA Inferred from Direct Assay more info	PubMed
located_in costamere	IDA Inferred from Direct Assay more info	PubMed
located_in muscle tendon junction	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kon-tiki

Names: CG10275-PB; CG10275-PC; CG10275-PD; Kon-tiki; NG2-like; kon-PB; kon-PC; kon-PD; kontiki; perdido

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033779.5 Reference assembly

Range

18487747..18503978 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001273610.1 → NP_001260539.1 kon-tiki, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260539.1

Status: REVIEWED

UniProtKB/TrEMBL

A3RLX3, Q9VJ82

Conserved Domains (2) summary

cd00110
Location:211 → 365

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam16184
Location:1436 → 1578

Cadherin_3; Cadherin-like
NM_136037.4 → NP_609881.3 kon-tiki, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_609881.3

Status: REVIEWED

UniProtKB/TrEMBL

A3RLX3, Q9VJ82

Conserved Domains (2) summary

cd00110
Location:211 → 365

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam16184
Location:1436 → 1578

Cadherin_3; Cadherin-like
NM_001273611.1 → NP_001260540.1 kon-tiki, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001260540.1

Status: REVIEWED

UniProtKB/TrEMBL

A3RLX3, Q9VJ82

Conserved Domains (2) summary

cd00110
Location:211 → 365

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

pfam16184
Location:1436 → 1578

Cadherin_3; Cadherin-like