U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR142 G protein-coupled receptor 142 [ Homo sapiens (human) ]

Gene ID: 350383, updated on 4-Nov-2022

Summary

Official Symbol
GPR142provided by HGNC
Official Full Name
G protein-coupled receptor 142provided by HGNC
Primary source
HGNC:HGNC:20088
See related
Ensembl:ENSG00000257008 MIM:609046; AllianceGenome:HGNC:20088
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PGR2; GPRg1b
Summary
GPR142 is a member of the rhodopsin family of G protein-coupled receptors (GPRs) (Fredriksson et al., 2003 [PubMed 14623098]).[supplied by OMIM, Mar 2008]
Expression
Biased expression in stomach (RPKM 1.1), spleen (RPKM 0.3) and 9 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GPR142 in Genome Data Viewer
Location:
17q25.1
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (74367506..74372600)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (75258167..75263271)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (72363645..72368739)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene kinesin family member 19 Neighboring gene uncharacterized LOC107985078 Neighboring gene BTB domain containing 17 Neighboring gene uncharacterized LOC124904055 Neighboring gene Sharpr-MPRA regulatory region 691

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cell junction IDA
Inferred from Direct Assay
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable G-protein coupled receptor 142
Names
G-protein coupled receptor 142 long form
G-protein coupled receptor PGR2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001331076.1NP_001318005.1  probable G-protein coupled receptor 142 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses two alternate splice junctions compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AY288421, BC143807
    Consensus CDS
    CCDS92387.1
    UniProtKB/Swiss-Prot
    Q7Z601
    UniProtKB/TrEMBL
    J3QSD0
    Related
    ENSP00000464632.2, ENST00000582579.6
  2. NM_001331077.1NP_001318006.1  probable G-protein coupled receptor 142 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AY288421, DY312809, DY312859
    Consensus CDS
    CCDS92387.1
    UniProtKB/Swiss-Prot
    Q7Z601
    UniProtKB/TrEMBL
    J3QSD0
  3. NM_181790.1NP_861455.1  probable G-protein coupled receptor 142 isoform a

    See identical proteins and their annotated locations for NP_861455.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AY288421
    Consensus CDS
    CCDS11698.1
    UniProtKB/Swiss-Prot
    Q7Z601, Q86SL3
    Related
    ENSP00000335158.4, ENST00000335666.4
    Conserved Domains (1) summary
    pfam00001
    Location:176414
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    74367506..74372600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    75258167..75263271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)