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IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) [ Homo sapiens (human) ]

Gene ID: 3502, updated on 12-Sep-2021

Summary

Official Symbol
IGHG3provided by HGNC
Official Full Name
immunoglobulin heavy constant gamma 3 (G3m marker)provided by HGNC
Primary source
HGNC:HGNC:5527
See related
Ensembl:ENSG00000211897 IMGT/GENE-DB:IGHG3; MIM:147120
Gene type
other
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IgG3
Annotation information
Annotation category: partial on reference assembly
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Genomic context

See IGHG3 in Genome Data Viewer
Location:
14q32.33
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (105765914..105771405, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (106232251..106237742, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107987211 Neighboring gene immunoglobulin heavy locus Neighboring gene uncharacterized LOC105378184 Neighboring gene ATP6V1G1P1-IGHD intergenic CAGE-defined B cell enhancer Neighboring gene ATPase H+ transporting V1 subunit G1 pseudogene 1 Neighboring gene immunoglobulin heavy constant gamma 1 (G1m marker)

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Other Names

  • C gamma 3
  • constant region of heavy chain of IgG3
  • immunoglobulin gamma 3 (Gm marker)
  • immunoglobulin heavy constant gamma 3 (Gm marker)
  • secrete-type Ig gamma heavy-chain

Clone Names

  • FLJ39988, FLJ40036, FLJ40253, FLJ40587, FLJ40789, FLJ40834, MGC45809, DKFZp686H11213

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antigen binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables immunoglobulin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in complement activation, classical pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, engulfment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in phagocytosis, recognition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of B cell activation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in retina homeostasis HEP PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_001019.6 

    Range
    1108940..1114431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    105765914..105771405 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187600.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    233683..239174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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